首页|Therapeutic potential of targeting protein tyrosine phosphatases in liver diseases
Therapeutic potential of targeting protein tyrosine phosphatases in liver diseases
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Protein tyrosine phosphorylation is a post-translational modification that regulates protein structure to modulate demic organisms'homeostasis and function.This physiological process is regulated by two enzyme families,protein tyrosine kinases(PTKs)and protein tyrosine phosphatases(PTPs).As an important regulator of protein function,PTPs are indispensable for maintaining cell intrinsic physiology in different systems,as well as liver physiological and pathological processes.Dysregulation of PTPs has been implicated in multiple liver-related diseases,including chronic liver diseases(CLDs),hepatocellular carcinoma(HCC),and liver injury,and several PTPs are being studied as drug therapeutic targets.There-fore,given the regulatory role of PTPs in diverse liver diseases,a collated review of their function and mechanism is necessary.Moreover,based on the current research status of targeted therapy,we empha-size the inclusion of several PTP members that are clinically significant in the development and progres-sion of liver diseases.As an emerging breakthrough direction in the treatment of liver diseases,this review summarizes the research status of PTP-targeting compounds in liver diseases to illustrate their po-tential in clinical treatment.Overall,this review aims to support the development of novel PTP-based treatment pathways for liver diseases.
Tyrosine phosphorylationPTPsSignal transductionCLDsHCCAllosteric inhibitorPROTACsDrug development
Ao Wang、Yi Zhang、Xinting Lv、Guang Liang
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Department of Pharmacy and Institute of Inflammation,Zhejiang Provincial Affiliated People's Hospital,Hangzhou Medical College,Hangzhou 310014,China
Key Laboratory of Natural Medicines of the Changbai Mountain,Ministry of Education,Yanbian University,Yanji 133002,China
Chemical Biology Research Center,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou 325035,China
National Natural Science Foundation of ChinaZhejiang Provincial Key Scientific Project
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