首页|Progranulin:A promising biomarker and therapeutic target for fibrotic diseases

Progranulin:A promising biomarker and therapeutic target for fibrotic diseases

扫码查看
原文链接
  • 万方数据
  • 维普
Progranulin(PGRN),a multifunctional growth factor-like protein expressed by a variety of cell types,serves an important function in the physiologic and pathologic processes of fibrotic diseases,including wound healing and the inflammatory response.PGRN was discovered to inhibit pro-inflammation effect by competing with tumor necrosis factor-alpha(TNF-α)binding to TNF receptors.Notably,excessive tissue repair in the development of inflammation causes tissue fibrosis.Previous investigations have indicated the significance of PGRN in regulating inflammatory responses.Recently,multiple studies have shown that PGRN was linked to fibrogenesis,and was considered to monitor the formation of fibrosis in multiple organs,including liver,cardiovascular,lung and skin.This paper is a comprehensive review summarizing our current knowledge of PGRN,from its discovery to the role in fibrosis.This is followed by an in-depth look at the characteristics of PGRN,consisting of its structure,basic function and intracellular signaling.Finally,we will discuss the potential of PGRN in the diagnosis and treatment of fibrosis.

ProgranulinFibrotic diseaseFibrosisInflammationBiomarkerTherapeutic targetPGRN/TNFR interactionSignaling pathway

Fan Yang、Ming-Han Cheng、Hai-Feng Pan、Jian Gao

展开 >

Pediatric Translational Medicine Institute,Shanghai Children's Medical Center School of Medicine,Shanghai Jiao Tong University Shanghai 200000,China

Department of Ophthalmology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China

Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,Hefei 230022,China

Inflammation and Immune Mediated Diseases Laboratory of Anhui Province,Hefei 230022,China

展开 >

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Traditional Chinese Medicine Inheritance and Innovation"Hundreds and Thousands"Talent Project:Young Qihuang Scholar

81274172814732678197363782373933

2024

10.1016/j.apsb.2024.04.026

药学学报(英文版)

药学学报(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.14(8)