The role of botanical triterpenoids and steroids in bile acid metabolism,transport,and signaling:Pharmacological and toxicological implications

扫码查看

原文链接

万方数据
维普

外文摘要：Bile acids(BAs)are synthesized by the host liver from cholesterol and are delivered to the intes-tine,where they undergo further metabolism by gut microbes and circulate between the liver and intestines through various transporters.They serve to emulsify dietary lipids and act as signaling molecules,regulating the host's metabolism and immune homeostasis through specific receptors.Therefore,disruptions in BA meta-bolism,transport,and signaling are closely associated with cholestasis,metabolic disorders,autoimmune dis-eases,and others.Botanical triterpenoids and steroids share structural similarities with BAs,and they have been found to modulate BA metabolism,transport,and signaling,potentially exerting pharmacological ortoxi-cological effects.Here,we have updated the research progress on BA,with a particular emphasis on new-found microbial BAs.Additionally,the latest advancements in targeting BA metabolism and signaling for disease treatment are highlighted.Subsequently,the roles of botanical triterpenoids in BA metabolism,transport,and signaling are examined,analyzing their potential pharmacological,toxicological,or drug interaction effects through these mechanisms.Finally,a research paradigm is proposed that utilizes the gut microbiota as a link to interpret the role of these important natural products in BA signaling.

外文关键词：

Bile acidTriterpenoidPhytosterolSaponinGut microbesCholestasisMetabolic disordersRheumatoid arthritis

作者：

Zichen Luo、Wei Zhou、Tong Xie、Weichen Xu、Chen Shi、Zihan Xiao、Yu Si、Yan Ma、Qingling Ren、Liuqing Di、Jinjun Shan

展开 >

作者单位：

Medical Metabolomics Center,Institute of Pediatrics,Jiangsu Key Laboratory of Children's Health and Chinese Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China

State Key Laboratory of Natural Medicines,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 210009,China

Jiangsu CM Clinical Medicine Innovation Center for Obstetrics,Gynecology,and Reproduction,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210001,China

National Institute of Biological Sciences,Beijing 102206,China

Jiangsu Engineering Research Center for Efficient Delivery System of TCM,School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China

展开 >

基金：

National Natural Science Foundation of ChinaInnovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine,ChinaPriority Academic Program Development of Jiangsu Higher Education InstitutionsQing Lan ProjectJiangsu CM Clinical Medicine Innovation Center for Obstetrics,Gynecology,and Reproduction,ChinaNATCM's Project of Highlevel Construction of Key TCM DisciplinesPostgraduate Research & Practice Innovation Program of Jiangsu Province,China

项目编号：

82274071ZYYCXTD-C-202208ZX02102KYCX23_2039

出版年：

2024

DOI：

10.1016/j.apsb.2024.04.027

药学学报(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.14(8)