首页|Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis

Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis

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Non-alcoholic steatohepatitis(NASH),an advanced form of non-alcoholic fatty liver disease(NAFLD),has emerged as the leading cause of liver failure and related death.Currently,no medication is specifically approved to treat NAFLD or NASH.Here we report that oral administration of honey vesicle-like nanoparticles(H-VLNs)to naturally aged mice protects the liver from NASH development.H-VLNs are dominantly taken up by Kupffer cells in the liver and suppress hepatic chronic inflammation and further development of fibrosis and nodule formation in aged mice.Besides their reported anti-inflammasome function,H-VLNs are found to inhibit the transcriptional activities of C-JUN and nuclear factor-kappa B(NF-κB).MicroRNAs miR5119 and miR5108 and phenolic compound luteolin in H-VLNs are identified in suppressing both the C-JUN and NF-κB pathways.Collectively,oral intake of H-VLNs represents a promising new user-friendly modality to prevent the development of NASH.

HoneyExtracellular vesiclesExosomesNanoparticlesmicroRNAsAgingInflammationNon-alcoholic steatohepatitis

Baolong Liu、Phuong Linh Nguyen、Han Yu、Xingzhi Li、Huiren Wang、Tram Gia Bao Nguyen、Prakash Kumar Sahoo、Meghna Sur、Jay Reddy、Sarah Sillman、Stephen D.Kachman、Bara Altartouri、Guoqing Lu、Sathish Kumar Natarajan、Mahesh Pattabiraman、Jiujiu Yu

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Department of Nutrition and Health Sciences,University of Nebraska-Lincoln,Lincoln,NE 68583,USA

Shaanxi Key Laboratory of Molecular Biology for Agriculture,College of Animal Science and Technology,Northwest A&F University,Yangling 712100,China

Department of Nutrition,Case Western Reserve University,Cleveland,OH 44106,USA

School of Veterinary Medicine and Biomedical Sciences,University of Nebraska-Lincoln,Lincoln,NE 68583,USA

Department of Statistics,University of Nebraska-Lincoln,Lincoln,NE 68583,USA

Center for Biotechnology,University of Nebraska-Lincoln,Lincoln,NE 68588,USA

Department of Biology,University of Nebraska Omaha,Omaha,NE 68182,USA

Department of Chemistry,University of Nebraska-Kearney,Kearney,NE 68849,USA

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United States Department of Agriculture(USDA)National Institute of Food and Agriculture(NIFA)Multistate Hatch ProjectUnited States Department of Agriculture(USDA)National Institute of Food and Agriculture(NIFA)Multistate Hatch ProjectUnited States Department of Agriculture(USDA)National Institute of Food and Agriculture(NIFA)Multistate Hatch ProjectNational Institutes of Health(NIH)Nebraska Center for Integrated Biomolecular Communication COBRE grantNebraska Center for Integrated Biomolecular Communication COBRE grantNebraska Center for Integrated Biomolecular Communication COBRE grantNebraska Research Initiative

10210802021-67017-34206USAR01DK124590USAP20 GM113126NIGMSUSA

2024

10.1016/j.apsb.2024.05.002

药学学报(英文版)

药学学报(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.14(8)