Remote-controlled dexamethasone-duration on eye-surface with a micelle-magnetic nanoparticulate co-delivery system for dry eye disease

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外文摘要：Dexamethasone(DEX)is used to treat ocular surface diseases.However,regulating DEX duration in tears while preventing its absorption into the anterior chamber is critical for balancing its ther-apy effects and the side effects.In this study,a novel magnetic nanoparticle(MNP)-micelle(MC)co-delivery system(MMDS)was developed.The MC moiety in the MMDS served as the carrier for DEX and the MNP part endowed the MMDS with magnetic-responsive properties.To extend its resi-dency,the MMDS was magnetically attracted by an external magnet after instilling,which acted as a precorneal drug-depot enabling a sustainable release of DEX in tears.With combination of magnet treat-ment,the topical instillation of MMDS@DEX significantly prolonged the DEX-retention in tears and increased the DEX-concentration in the cornea and conjunctiva,as well as concurrently reduced the DEX-level in the aqueous humor,when compared with the commercial DEX eye drop treatment.The combination of MMDS@DEX and magnet treatment exerted significantly better therapeutic effects against DED with smaller side effects than conventional treatments including DEX suspension,commer-cial DEX eye drops,as well as the MMDS@DEX treatment alone.The present work provided a new method for the effective delivery of DEX to ocular surface tissues while reducing its side effects,which will be beneficial to the treatments of a wide range of ocular surface diseases.

外文关键词：

Magnetic nanoparticleMicelleDexamethasoneEye dropBioavailabilityDry eye diseaseCorneaConjunctiva

作者：

Qinxiang Zheng、Chaoxiang Ge、Kexin Li、Longxin Wang、Xiaoyu Xia、Xiao Liu、Rashid Mehmood、Jianliang Shen、Kaihui Nan、Wei Chena、Sen Lin

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作者单位：

National Engineering Research Center of Ophthalmology and Optometry,Eye Hospital,Wenzhou Medical University,Wenzhou 325027,China

National Clinical Research Center for Ocular Diseases,Eye Hospital,Wenzhou Medical University,Wenzhou 325027,China

School of Chemical Engineering,UNSW Sydney,High Street,Building E10,Kensington,NSW 2052,Australia

Adult Cancer Program,Lowy Cancer Research Centre,UNSW Sydney,Corner Botany & High Streets,Kensington,NSW 2052,Australia

Zhejiang Engineering Research Center for Tissue Repair Materials,Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325000,China

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基金：

National Natural Science Foundation of ChinaZhejiang Provincial Natural Science Foundation of Chinainternal funding of Wenzhou Medical University,ChinaProject of Wenzhou Medical University Affiliated Eye Hospital,Chinaintegration project of State Key Laboratory of Ophthalmology,Optometry and Vision Science,China

项目编号：

82070932LY19H120002KYYW202020YNZD2201901J02-20190202

出版年：

2024

DOI：

10.1016/j.apsb.2024.05.004

药学学报(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.14(8)