首页|The role of the microbiota-gut-brain axis in methamphetamine-induced neurotoxicity:Disruption of microbial composition and short-chain fatty acid metabolism
The role of the microbiota-gut-brain axis in methamphetamine-induced neurotoxicity:Disruption of microbial composition and short-chain fatty acid metabolism
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维普
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Methamphetamine(METH)abuse is associated with significant neurotoxicity,high addiction potential,and behavioral abnormalities.Recent studies have identified a connection between the gut microbiota and METH-induced neurotoxicity and behavioral disorders.However,the underlying causal mechanisms linking the gut microbiota to METH pathophysiology remain largely unexplored.In this study,we employed fecal microbiota transplantation(FMT)and antibiotic(Abx)intervention to mani-pulate the gut microbiota in mice administered METH.Furthermore,we supplemented METH-treated mice with short-chain fatty acids(SCFAs)and pioglitazone(Pio)to determine the protective effects on gut microbiota metabolism.Finally,we assessed the underlying mechanisms of the gut-brain neural circuit in vagotomized mice.Our data provide compelling evidence that modulation of the gut micro-biome through FMT or microbiome knockdown by Abx plays a crucial role in METH-induced neurotox-icity,behavioral disorders,gut microbiota disturbances,and intestinal barrier impairment.Furthermore,our findings highlight a novel prevention strategy for mitigating the risks to both the nervous and intes-tinal systems caused by METH,which involves supplementation with SCFAs or Pio.
Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification,School of Forensic Medicine,Southern Medical University,Guangzhou 510515,China
Shunde Police in Foshan City,Foshan 528300,China
Department of Toxicology,School of Public Health,Southern Medical University(Guangdong Provincial Key Laboratory of Tropical Disease Research),Guangzhou 510515,China
维普
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