首页|Recent advances in reactive oxygen species(ROS)-responsive drug delivery systems for photodynamic therapy of cancer
Recent advances in reactive oxygen species(ROS)-responsive drug delivery systems for photodynamic therapy of cancer
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Reactive oxygen species(ROS)-responsive drug delivery systems(DDSs)have garnered signif-icant attention in cancer research because of their potential for precise spatiotemporal drug release tailored to high ROS levels within tumors.Despite the challenges posed by ROS distribution heterogeneity and endogenous supply constraints,this review highlights the strategic alliance of ROS-responsive DDSs with photodynamic therapy(PDT),enabling selective drug delivery and leveraging PDT-induced ROS for enhanced therapeutic efficacy.This review delves into the biological importance of ROS in cancer progres-sion and treatment.We elucidate in detail the operational mechanisms of ROS-responsive linkers,including thioether,thioketal,selenide,diselencide,telluride and aryl boronic acids/esters,as well as the latest devel-opments in ROS-responsive nanomedicines that integrate with PDT strategies.These insights are intended to inspire the design of innovative ROS-responsive nanocarriers for enhanced cancer PDT.
Rehabilitation Medicine Center and Institute of Rehabilitation Medicine,Cancer Center and State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu 610041,China
Key Laboratory of Rehabilitation Medicine in Sichuan Province,West China Hospital,Sichuan University,Chengdu 610041,China
Department of Orthopedics,West China Hospital,Sichuan University,Chengdu 610041,China
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