首页|Comparison of Jinzhen oral liquid and ambroxol hydrochloride and clenbuterol hydrochloride oral solution in the treatment of acute bronchitis in children:A multicenter,non-inferiority,prospective,randomized controlled trial

Comparison of Jinzhen oral liquid and ambroxol hydrochloride and clenbuterol hydrochloride oral solution in the treatment of acute bronchitis in children:A multicenter,non-inferiority,prospective,randomized controlled trial

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The comparison between traditional Chinese medicine Jinzhen oral liquid(JZOL)and West-ern medicine in treating children with acute bronchitis(AB)showed encouraging outcomes.This trial eval-uated the efficacy and safety of the JZOL for improving cough and expectoration in children with AB.480 children were randomly assigned to take JZOL or ambroxol hydrochloride and clenbuterol hydrochloride oral solution for 7 days.The primary outcome was time-to-cough resolution.The median time-to-cough resolution in both groups was 5.0 days and the antitussive onset median time was only 1 day.This random-ized controlled trial showed that JZOL was not inferior to cough suppressant and phlegm resolving western medicine in treating cough and sputum and could comprehensively treat respiratory and systemic discom-fort symptoms.Combined with clinical trials,the mechanism of JZOL against AB was uncovered by network target analysis,it was found that the pathways in TRP channels like IL-1β/IL1R/TRPV1/TRPA1,NGF/TrkA/TRPVl/TRPA1,and PGE2/EP/PKA/TRPV1/TRPA1 might play important roles.Animal ex-periments further confirmed that inflammation and the immune regulatory effect of JZOL in the treatment of AB were of vital importance and TRP channels were the key mechanism of action.

Acute bronchitisJinzhen oral liquidComplementary and alternative medicineClinical trialNetwork target analysis

Qinhua Fan、Chongming Wu、Yawei Du、Boyang Wang、Yanming Xie、Zeling Zhang、Wenquan Su、Zizhuo Wang、Changchang Xu、Xueke Li、Ying Ding、Xinjiang An、Jing Chen、Yunying Xiao、Rong Yu、Nan Li、Juan Wang、Yiqun Teng、Hongfen Lv、Nian Yang、Yuling Wen、Xiaoli Huang、Wei Pan、Yufeng Liu、Xueqin Xi、Qianye Zhao、Changshan Liu、Jian Xu、Haitao Zhang、Lie Zhuo、Qiangquan Rong、Yu Xia、Qin Shen、Shao Li、Junhong Wang、Shengxian Wu

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Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China

School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China

Institute for TCM-X,MOE Key Laboratory of Bioinformatics,Bioinformatics Division,BNRist,Department of Automation,Tsinghua University,Beijing 100084,China

Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China

The First Affiliated Hospital of Henan University of CM,Zhengzhou 450099,China

Xuzhou Children's Hospital,Xuzhou 221002,China

Women and Children's Health Care Hospital of Linyi,Linyi 276016,China

Taian Maternity and Child Health Hospital,Taian 271001,China

Wuxi No.8 People's Hospital Group,Wuxi 214011,China

Shi Jia Zhuang Maternity & Child Healthcare Hospital,Shijiazhuang 050006,China

The First People's Hospital of Lianyungang,Lianyungang 222002,China

Jiaxing Second Hospital,Jiaxing 314001,China

Jiangyan Hospital of Traditional Chinese Medicine,Taizhou 225599,China

Linshu County People's Hospital,Linyi 276799,China

Qiqihar Hospital of Traditional Chinese Medicine,Qiqihar 161005,China

Liuzhou Maternal and Child Health Care Hospital,Liuzhou 545001,China

Wuxi Hospital of Traditional Chinese Medicine,Wuxi 214071,China

The Fourth Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110103,China

Shandong Maternal and Child Health Hospital,Jinan 250014,China

Lianyungang Maternal and Child Health Hospital,Lianyungang 222062,China

The Second Hospital of Tianjin Medical University,Tianjin 300211,China

Qidong Maternal and Child Health Hospital,Qidong 226299,China

Suzhou Integrated Traditional and Western Medicine Hospital,Suzhou 215101,China

Nanjing Drum Tower Hospital Group Suqian Hospital,Nanjing 210008,China

Nanjing Gaochun People's Hospital,Nanjing 211302,China

Nanjing Lishui People's Hospital,Nanjing 211299,China

The Affiliated Suqian First People's Hospital of Nanjing Medical University,Suqian 223812,China

State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture,Lianyungang 222047,China

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2024

10.1016/j.apsb.2024.09.001

药学学报(英文版)

药学学报(英文版)

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年,卷(期)：2024.14(12)