首页|Pretheranostic agents with extraordinary NIRF/photoacoustic imaging performance and photothermal oncotherapy efficacy
Pretheranostic agents with extraordinary NIRF/photoacoustic imaging performance and photothermal oncotherapy efficacy
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Cervical cancer,the most common gynecological malignancy,significantly and adversely af-fects women's physical health and well-being.Traditional surgical interventions and chemotherapy,while potentially effective,often entail serious side effects that have led to an urgent need for novel therapeutic methods.Photothermal therapy(PTT)has emerged as a promising approach due to its ability to minimize damage to healthy tissue.Connecting a biothiol detection group to PTT-sensitive molecules can improve tumor targeting and further minimize potential side effects.In this study,we developed a near-infrared fluorescence(NIRF)/photoacoustic(PA)dual-mode probe,S-NBD,which demonstrated robust PTT per-formance.This innovative probe is capable of activating NIRF/PA signals to enable the detection of bio-thiols with high emission wavelength(838 nm)and large Stokes shift(178 nm),allowing for in vivo monitoring of cancer cells.Additionally,the probe achieved an outstanding photothermal conversion ef-ficiency of 67.1％.The application of laser irradiation(660 nm,1.0 W/cm2,5 min)was able to achieve complete tumor ablation without recurrence.In summary,this seminal study presents a pioneering NIRF/PA dual-mode dicyanoisophorone-based probe for biothiol imaging,incorporating features from PTT for the first time.This pioneering approach achieves the dual objectives of improving tumor diagnosis and treatment.
Biothiol detectionNear-infrared fluorescence(NIRF)imagingPhotoacoustic(PA)imagingPhotothermal therapy(PTT)Cervical cancer
Liu Shi、Zhenzhou Chen、Jiaxin Ou、En Liang、Zhipeng Chen、Qiuyue Fu、Lan Huang、Kui Cheng
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Guangdong Provincial Key Laboratory of New Drug Screening,NMPA Key Laboratory for Research and Evaluation of Drug Metabolism and Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening,School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China
State Key Laboratory of Organ Failure Research,Key Laboratory of Infectious Diseases Research in South China,Ministry of Education,Southern Medical University,Guangzhou 510515,China
Jieyang Medical Research Center,Jieyang People's Hospital,Jieyang 522000,China
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