首页|Counteracting Alzheimer's disease via normalizing neurovascular unit with a self-regulated multi-functional nano-modulator
Counteracting Alzheimer's disease via normalizing neurovascular unit with a self-regulated multi-functional nano-modulator
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The neurovascular unit(NVU)is highly responsible for cerebral homeostasis and its dysfunc-tion emerges as a critical contributor to Alzheimer's disease(AD)pathology.Hence,rescuing NVU dysfunction might be a viable approach to AD treatments.Here,we fabricated a self-regulated muti-func-tional nano-modulator(siR/PIO@RP)that can intelligently navigate to damaged blood-brain barrier and release therapeutical cargoes for synergetic AD therapy.The resulting siR/PIO@RP enables self-regulation of its distribution in accordance with the physio/pathological state(low/high RAGE expression)of the target site via a feedback loop.siR/PIO@RP is capable of performing intricate tasks and goes beyond the capabilities of single-target therapeutic agents utilized in AD therapy,such as reducing cerebral Aβ load,relieving neuroinflammation,and alleviating the dysfunction of NVU.Overall,the current study provides proof of concept that normalizing NVU holds promise as a means of alleviating AD symptoms.
Alzheimer's diseaseTargeted deliveryPathological blood-brain barrierNeurovascular unitReceptor for advanced glycation end productsGene deliveryAnti-inflammationSynergetic therapy
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,West China School of Pharmacy,Mental Health Center and National Chengdu Center for Safety Evaluation of Drugs,West China Hospital,Sichuan University,Chengdu 610041,China
Key Laboratory of Coarse Cereal Processing,School of Food and Biological Engineering,Chengdu University,Chengdu 610106,China
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