吲哚美辛在儿童颅骨嗜酸性肉芽肿中的应用
Indomethacin Therapy in Eosinophilic Granuloma of the Skull in Children
李江 1陈芙庭 1徐将荣1
作者信息
- 1. 315020 宁波大学医学院附属医院神经外科
- 折叠
摘要
目的 探讨吲哚美辛在儿童颅骨嗜酸性肉芽肿病变中应用的有效性和安全性.方法 2008年1月～ 2014年1月期间笔者医院神经外科就诊的16位颅骨嗜酸性肉芽肿病变儿童,在病理检查取得支持后,给予6 ～12周吲哚美辛口服治疗,其中吲哚美辛口服前肿物全切12例,活检1例,3例多发者行部分切除.回顾性分析这16例患者的临床资料及治疗效果.结果 16例患者对吲哚美辛耐受良好,本组内未见复发病例.结论 吲哚美辛对儿童颅骨嗜酸性肉芽肿治疗初步显示了较好效果,但未来需要更多研究.
Abstract
Objective To explore the recommendations for indomethacin in the treatment of eosinophilic granuloma(EG) of the skull in children.Methods The data of 16 cases with EG of the skull in department of neurosurgery were retrospectively analyzed.Biopsies were performed in all patients (incisional in 3,excisional in 12,and percutaneous in 1).Indomethacin,has been used in this group of patients for about 6-12 weeks.Results Of 16 cases,no child had recurrence,and indomethacin was well tolerated.Conclusion As for children with EG of the skull,indomethacin therapy seems to be effective,more research are needed in the future.
关键词
嗜酸性肉芽肿/朗格汉斯细胞组织细胞增生症/吲哚美辛Key words
Eosinophilic granuloma/Langerhans cell histiocytosis/Indomethacin引用本文复制引用
基金项目
宁波市自然科学基金(2013A610251)
出版年
2015
NETL
NSTL
维普
万方数据