Clinical Pharmacokinetic and Pharmacodynamic Study of Ambroxol Inhalation and Intravenous Treatment
Objective To study the clinical pharmacokinetic of ambroxol hydrochloride inhalation and intravenous administration routines and evaluate the effectiveness of ambroxol administration.Methods Twelve male patients with symptoms of phlegm difficult to discharge of respiratory disease (normal liver and kidney function) were randomly divided into two groups,treated using initially atomized ambroxol then intravenous injection treatment after elution for a week,and ambroxol initial intravenous injection then atomized ambroxol treatment after elution.We determined the corresponding pharmacokinetic parameters by HPLC in sputum and blood,such as the drug concentration-time curve area under the AUC (plasma)/AUC (sputum),peak concentration,time to peak and investigating the relevance of pharmacokinetics and pharmacodynamics by combining clinical efficacy.Results The Tmax,Cmax and AUC of plasma in the administration ways were basically the same,but the Tmax,Cmax,AUC of the sputum in atomization administration were higher than that in intravenous injection,the clinical improvement rate of inhalation therapy was superior to that of intravenous treatment.Conclusion Ambroxol hydrochloride administered via inhalation had a better clinical effect compared with intravenous administration.
NETL
NSTL
万方数据
维普
