Effect of Colchicine on the Prognosis of Rats After Myocardial Infarction
Objective To investigate the effect of Colchicine on the prognosis of acute myocardial infarction(MI)in rats.Methods A total of 40male Sprague Dawley rats were randomly divided into 4groups:Sham operation group,MI+BLS(blank solvent)group,MI+Colchicine treatment group(MI+col/i.g),and MI+Colchicine intramyocardial injection(MI+col/i.m)group,with 10 rats in each group.We euthanized the rats 28days after modeling,recorded the rats'body weight and death,collected echocardiography,detec-ted the levels of serum inflammatory factors,liver and kidney functions by enzyme-linked immunosorbent assay(ELISA),stained the cardiac tissue samples by Masson,and analyzed the degree of myocardial fibrosis under Optical microscope.Results The survival rate within 28days after MI was not significantly improved by Colchicine.Compared with the model group,both Colchicine intragastric adminis-tration and intramyocardial injection could significantly reduce the serum inflammatory factors(P＜0.05),inhibit the myocardial fibrosis,and improve the cardiac function of the rats after MI(P＜0.001).The liver and kidney functions were not damaged in the Colchicine and intramyocardial injection groups,and the intramyocardial injection group could effectively alleviate the weight loss induced by systemic ad-ministration(P＜0.001).Conclusion Colchicine is safe and feasible in the treatment of MI in rats,it can significantly improve the car-diac function of rats after MI,and intramyocardial injection can effectively and significantly increase the tolerance of colchicine.
万方数据
维普
