首页|瓣叶图案化对机械瓣膜流体力学性能的影响

瓣叶图案化对机械瓣膜流体力学性能的影响

扫码查看
目的 探讨在机械瓣瓣叶表面构建图案化织构是否对机械瓣流体力学性能产生影响.方法 分别随机抽取GKS 21A、23A两种规格的双叶主动脉机械瓣,作为对照组按照ISO 5840-2:2021标准要求用脉动流测试仪测试瓣膜的平均跨瓣压差(mean transvalvular pressure,MTP)、反流百分比(regurgitation fraction,RE)、有效开 口面积(effective orifice area,EOA)、能量损耗(energy loss,eLoss)等流体力学指标;然后用激光刻蚀的方法在每个瓣叶表面构建垂直于血流方向的横纹图案,再次对该实验组瓣膜进行同样的测试,记录、分析所得数据.结果 在脉动流试验中,实验组的MTP在相同流量、规格下比对照组小;GKS 21A实验组瓣膜的RE比对照组小,GKS23A实验组瓣膜的RE比对照组大;实验组瓣膜的EOA在相同流量、规格下均比对照组大;GKS21A实验组瓣膜的eLoss比对照组小,GKS 23A实验组瓣膜的eLoss比对照组大.结论 机械瓣瓣叶表面横纹图案会影响到瓣膜的血流动力学性能.
Effect of Leaflet Pattering on Mechanical Valve Hydrodynamic Properties
Objective To investigate the effects patterned structure located on the surface of mechanical valve leaflet exerted on the hydrodynamic properties of valve prostheses.Methods Bileaflet aortic mechanical valves of GKS 21A and 23 A were randomly selected as the control group,hydrodynamic performance of each valve were assessed,as per ISO5840 by calculating mean transvalvular pressure(MTP),regurgitation fraction(REG),effective orifice area(EOA)and effective orifice area(eLoss).Then,laser etching was applied to construct a parallel-groove array pattern on leaflet surface perpendicular to the direction of the blood flow.The valve was subjected a-gain to the same test,and the data obtained were recorded and analyzed.Results In the pulsating flow test,the MTP of the experimental group was smaller than that of the control group at the same flow rate and size.The RE in GKS 21A experimental group was smaller than that in control group,and the RE in GKS 23A experimental group was larger than that in control group.The EOA in the experimental group was larger than that in the control group at the same flow rate and size.The eLoss in the GKS 21A experimental group was smaller than that in the control group,and the eLoss in the GKS 23A experimental group was larger than that in the control group.Conclusion The parallel-groove array pattern on the surface of the leaflet affected the hemodynamic performance of the valve prostheses.

Patterns of leafletsHemodynamicsPulse duplicatorHeart valve prosthesis

王玉苗、周建业、刘丽

展开 >

100037 中国医学科学院/北京协和医学院阜外心血管病医院、国家心血管病中心、心血管疾病国家重点实验室

102629 北京,中国食品药品检定研究院

表面图案化 血流动力学 脉动流测试仪 人工心脏瓣膜

国家重点研发计划项目

2018YFC1105502

2024

医学研究杂志
中国医学科学院

医学研究杂志

CSTPCD
影响因子:0.702
ISSN:1673-548X
年,卷(期):2024.53(2)
  • 20