目的 探讨结肠息肉内镜下切除后再发的危险因素.方法 244例行内镜下结肠息肉治疗的患者,根据术后首次肠镜复查结果分为再发组(n=168)和未再发组(n=76),比较两组的基本资料、生化指标、息肉特征、手术方式等,采用多因素Logistic回归分析评价结肠息肉切除后再发的危险因素.结果 244例患者再发168例(68.9％),再发组年龄(60.17±10.54岁)、息肉数目[3(2,5)个]大于未再发组[56.30±11.08岁、2(1,4)个],差异均有统计学意义(P＜0.05).男性、年龄＞58岁、息肉数目≥3个、息肉分布于全结肠、多部位息肉及癌前息肉比例(71.4％、58.3％、60.1％、54.8％、63.7％、75.6％)均高于未再发组(48.7％、42.1％、34.2％、30.3％、42.1％、61.8％),差异均有统计学意义(P＜0.05).再发组高密度脂蛋白(high density lip-oprotein,HDL)水平[1.08(0.90,1.31)mmol/L]低于未再发组[1.21(0.96,1.40)mmol/L](U=-2.321,P=0.020),息肉分布于右半结肠比例(19.0％)低于未再发组(31.6％)(x2=4.647,P=0.031).男性(OR=2.375,95％CI:1.222～4.616,P=0.011)、年龄(OR=1.036,95％CI:1.007～1.065,P=0.013)、息肉分布于全结肠(OR=2.009,95％CI:1.039～3.886,P=0.038)是结肠息肉内镜下切除后再发的独立危险因素.结论 男性、年龄较大、息肉分布于全结肠的患者更易在内镜下息肉切除后再发.
Risk Factors for Recurrence of Colonic Polyps after Endoscopic Resection
Objective To investigate the risk factors for recurrence of colon polyps after endoscopic resection.Methods Two hun-dred and forty-four patients who were treated with endoscopic colon polyps were divided into recurrence group(n=168)and non-re-currence group(n=76)according to the results of the first postoperative colonoscopy review,the basic data,biochemical indexes,polyp characteristics and surgical methods of the two groups were compared,and the risk factors of recurrence after resection of colon polyps were evaluated by multivariate Logistic regression analysis.Results There were 168 recurrences in 244 patients(68.9％),the age[60.17± 10.54 years old]and number of polyps[3(2,5)]in the recurrence group[56.30±11.08 years old and 2(1,4)]were higher than in the non-recurrence group,the differences were statistically significant(P＜0.05).The proportion of males,age＞58 years old,num-ber of polyps ≥3,polyps distributed in the whole colon,multi-site polyps and polyps at risk of malignant transformation(71.4％,58.3％,60.1％,54.8％,63.7％,75.6％)were higher than those in the non-recurrence group(48.7％,42.1％,34.2％,30.3％,42.1％,61.8％),and the differences were statistically significant(P＜0.05),and the HDL(high density lipoprotein)level in the recurrence group[1.08(0.90,1.31)mmol/L]was lower than that in the non-recurrence group[1.21(0.96,1.40)mmol/L](U=-2.321,P=0.020),and the proportion of polyp distribution in the right hemi-colon(19.0％)was lower than in the non-recurrence group(31.6％)(x2=4.647,P=0.031).The proportion of polyp distribution in men(OR=2.375,95％CI:1.222-4.616,P=0.011),age(OR=1.036,95％CI:1.007-1.065,P=0.013),and polyp distribution in the whole colon(OR=2.009,95％CI:1.039-3.886,P=0.038)were independent risk factors for recurrence of colon polyps after endoscopic resection.Conclusion Pa-tients who were male,older,and had polyps distributed in the whole colon were more likely to recur after endoscopic polypectomy.
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