Analysis of Clinical Characteristics and Influencing Factors of Outcome in Patients with Tuberculosis Complicated with Diabetes
Objective To analyze the clinical characteristics and influencing factors of outcomes of patients with tuberculosis compli-cated with diabetes in southern Xinjiang.Methods The clinical data of tuberculosis patients in the Second People's Hospital of Aksu,Kuqa Infectious Disease Hospital in Aksu District,and Kashgar Pulmonary Hospital from July 2018 to January 2019 were collected,and they were divided into tuberculosis combined with diabetes(TB+DM)group and simple tuberculosis(TB)group according to the pres-ence or absence of diabetes.Univariate analysis was used to compare the general conditions,clinical symptoms,and laboratory indicators of the two groups of patients and their different blood glucose control conditions.COX regression analysis was used to evaluate the inde-pendent related factors that affect the 6-month sputum negative in diabetic patients with pulmonary tuberculosis.Results Among the 293 cases of tuberculosis,36 cases were in the TB+DM group,including 18males and 18 were females,and 257 were in the TB group,including 154males and 103 females.The results of univariate analysis showed that the time of sputum culture,age,blood glucose con-trol,fever,night sweats,triglycerides(TG),aspartate transaminase(AST),platelet(PLT),and triglyceride(TG),cholesterol(TC),cumulative lung field and newly diagnosed bacterial load were significantly different between the groups under different blood glu-cose control conditions(P＜0.05).The results of multivariate COX regression analysis showed that blood glucose control(HR=61.179,95％CI:6.338-590.549),night sweats(HR=0.085,95％CI:0.018-0.412),and initial diagnosis of bacterial load(HR=0.487,95％CI:0.268-0.885)were the independent related factors that affects the 6-month sputum culture.Conclusion Disorders of glucose and lipid metabolism in patients with tuberculosis complicated with diabetes promote the growth of mycobacterium tuberculosis and damage the body's resistance to mycobacterium tuberculosis,while night sweats,large amount of bacteria in initial diagnosis and poor blood glucose control can prolong the time of sputum turning negative and affect the prognosis of patients.Therefore,early identification of related factors,attention to the treatment of complicated diabetes and timely individualized treatment can help shorten the time of sputum turning negative,reduce the medical burden on the society and patients
万方数据
维普
