首页|变应性鼻炎对SARS-CoV-2感染的影响调查

变应性鼻炎对SARS-CoV-2感染的影响调查

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目的 探讨患有变应性鼻炎(allergic rhinitis,AR)是否会影响新型冠状病毒(SARS-CoV-2)感染的比率和严重程度.方法 招募AR患者及无AR的对照者,进行单中心回顾性问卷调查.问卷内容包括受访者的基本人口学特征,是否有SARS-CoV-2感染,感染症状的严重程度评分,以及可能影响感染严重度的危险因素,完成问卷后进行统计分析.结果 AR组SARS-CoV-2感染率为83.9%(162/193),对照组感染率为86.0%(166/193),两组比较差异无统计学意义(P>0.05).AR组的感染症状严重度总评分为10(7,14)分,与对照组[10(6,13)分]比较,差异无统计学意义(P>0.05).AR患者感染SARS-CoV-2后的憋气、呕吐、腹泻症状要比对照组更严重.男性AR患者的SARS-CoV-2感染症状严重度总评分[8.0(5.8,11.0)分]低于女性AR患者[10.5(8.0,14.0)分],差异有统计学意义(P=0.002).结论 在本研究调查的SARS-CoV-2感染轻症群体中,AR患者与对照组的感染率及严重度均未见差异,但性别可能会影响AR患者感染症状的严重程度.
Investigation on the Influence of Allergic Rhinitis on SARS-CoV-2 Infection
Objective To explore whether suffering from allergic rhinitis(AR)would affect the rate and severity of severe acute re-spiratory syndrome coronavirus 2(SARS-CoV-2)infection.Methods A single-center retrospective questionnaire survey was con-ducted in AR patients and non-AR controls.The questionnaire includes the basic demographic characteristics of the respondents,wheth-er they had SARS-CoV-2 infection,the severity score of infection symptoms,and the risk factors that may affect the severity of infec-tion.Statistical analysis was conducted after completing the questionnaire.Results The infection rate of SARS-CoV-2 was 83.9%(162/193)in AR group and 86.0%(166/193)in control group,there was no significant difference between the two groups(P>0.05).There was no significant difference in the total severity score of infection symptoms between AR group[10(7,14)]and control group[10(6,13)](P>0.05).The symptoms of suffocation,vomiting and diarrhea in AR patients infected with SARS-CoV-2 were more severe than those in controls.The total severity score of SARS-CoV-2 infection symptoms in male AR patients was 8.0(5.8,11.0),which was significantly lower than that in female AR patients[10.5(8.0,14.0)],and the difference was statistically significant(P=0.002).Conclusion There was no significant difference in the infection rate and severity between AR patients and controls in the mild SARS-CoV-2 infected subjects of this study,but gender might affect the severity of infection symptoms in AR patients.

SARS-CoV-2Allergic rhinitisSeverityRisk factors

李丽莎、关凯、王子熹、崔乐、王良录

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100730 中国医学科学院/北京协和医学院北京协和医院变态反应科、过敏性疾病精准诊疗研究北京市重点实验室、国家皮肤与免疫疾病临床医学研究中心、协和转化医学中心

新型冠状病毒 变应性鼻炎 严重度 危险因素

北京市自然科学基金中国医科院医学与健康科技创新工程项目中央高水平医院临床科研业务费项目

72221362021-I2M-1-0172022-PUMCH-B-089

2024

医学研究杂志
中国医学科学院

医学研究杂志

CSTPCD
影响因子:0.702
ISSN:1673-548X
年,卷(期):2024.53(3)
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