经皮微波消融术前血清VEGF和Ang-2水平与Ⅰ期非小细胞肺癌患者预后的相关性
Correlation between Serum VEGF and Ang-2 Levels and the Prognosis of Patients with Stage Ⅰ Non-small Cell Lung Cancer before Percu-taneous Microwave Ablation
杨文魁 1周志刚 2张琼 1梁志华 1栗敏 3秦靖宜 4陶兴5
作者信息
- 1. 450000 郑州人民医院医学影像科
- 2. 450000 郑州大学第一附属医院影像介入与核医学
- 3. 450000 郑州人民医院肿瘤内科
- 4. 450000 郑州人民医院普通外科
- 5. 450000 郑州第二人民医院院长办公室
- 折叠
摘要
目的 探讨术前血清血管内皮生长因子(vascular endothelial growth factor,VEGF)和血管生成素-2(angiopoietin-2,Ang-2)在经皮微波消融术(microwave ablation,MWA)治疗Ⅰ期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者预后评估中的价值.方法 收集2017年1月～2019年1月在郑州人民医院接受MWA治疗的Ⅰ期NSCLC患者106例(NSCLC组),同时选取50例健康者为对照组.采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测术前血清VEGF和Ang-2含量,采用Kaplan-Meier及COX回归分析评价VEGF和Ang-2与Ⅰ期NSCLC患者无复发生存期(recurrence-free sur-vival,RFS)和总生存期(over survival,OS)的关系.结果 NSCLC组患者术前VEGF和Ang-2水平明显高于对照组(P＜0.05);稳定和进展者术前VEGF和Ang-2水平分别明显高于完全缓解和部分缓解者(P＜0.05);复发和死亡患者术前VEGF和Ang-2水平分别明显高于未复发和生存患者(P＜0.05).术前高VEGF和Ang-2水平患者的RFS和OS明显低于低VEGF和Ang-2水平患者(P＜0.05),且两者均是RFS和OS的独立影响因素.结论 MWA术前血清VEGF和Ang-2水平与Ⅰ期NSCLC患者预后密切相关,具有一定的临床应用价值.
Abstract
Objective To investigate the prognostic value of preoperative serum vascular endothelial growth factor(VEGF)and an-giopoietin-2(Ang-2)in patients with stage Ⅰ non-small cell lung cancer(NSCLC)treated by percutaneous microwave ablation(MWA).Methods A total of 106 stage Ⅰ NSCLC patients(NSCLC group)treated by MWA in People's Hospital of Zhengzhou from January 2017 to January 2019 were collected,50healthy subjects were selected as the control group.The preoperative serum VEGF and Ang-2 levels were determined by enzyme-linked immunosorbent assay(ELISA).Kaplan-Meier and COX regression analysis were used to analyze the relationship between VEGF and Ang-2 and relapse-free survival(RFS)and overall survival(OS)in patients with stage Ⅰ NSCLC.Results The preoperative levels of VEGF and Ang-2 in the NSCLC group were significantly higher than those of the control group(P＜0.05).The preoperative levels of VEGF and Ang-2 in the patients with stable and progressive response were signifi-cantly higher than that with complete and partial response(P＜0.05).The preoperative levels of VEGF and Ang-2 in patients with re-currence and death were significantly higher than in patients without recurrence and survival,respectively(P＜0.05).The RFS and OS of patients with high VEGF and Ang-2 level were significantly lower than those of patients with low VEGF and Ang-2 level(P＜0.05),and both were independent influencing factors of RFS and OS.Conclusion Serum VEGF and Ang-2 levels before MWA were closely related to the prognosis of patients with stage Ⅰ NSCLC patients,which have certain clinical application value.
关键词
血管内皮生长因子/血管生成素-2/微波消融术/预后Key words
Vascular endothelial growth factor/Angiogenin-2/Microwave ablation/Prognosis引用本文复制引用
基金项目
河南省中医药研究专项(2019JDZX2124)
出版年
2024
NETL
NSTL
万方数据