Correlation between Serum VEGF and Ang-2 Levels and the Prognosis of Patients with Stage Ⅰ Non-small Cell Lung Cancer before Percu-taneous Microwave Ablation
Objective To investigate the prognostic value of preoperative serum vascular endothelial growth factor(VEGF)and an-giopoietin-2(Ang-2)in patients with stage Ⅰ non-small cell lung cancer(NSCLC)treated by percutaneous microwave ablation(MWA).Methods A total of 106 stage Ⅰ NSCLC patients(NSCLC group)treated by MWA in People's Hospital of Zhengzhou from January 2017 to January 2019 were collected,50healthy subjects were selected as the control group.The preoperative serum VEGF and Ang-2 levels were determined by enzyme-linked immunosorbent assay(ELISA).Kaplan-Meier and COX regression analysis were used to analyze the relationship between VEGF and Ang-2 and relapse-free survival(RFS)and overall survival(OS)in patients with stage Ⅰ NSCLC.Results The preoperative levels of VEGF and Ang-2 in the NSCLC group were significantly higher than those of the control group(P＜0.05).The preoperative levels of VEGF and Ang-2 in the patients with stable and progressive response were signifi-cantly higher than that with complete and partial response(P＜0.05).The preoperative levels of VEGF and Ang-2 in patients with re-currence and death were significantly higher than in patients without recurrence and survival,respectively(P＜0.05).The RFS and OS of patients with high VEGF and Ang-2 level were significantly lower than those of patients with low VEGF and Ang-2 level(P＜0.05),and both were independent influencing factors of RFS and OS.Conclusion Serum VEGF and Ang-2 levels before MWA were closely related to the prognosis of patients with stage Ⅰ NSCLC patients,which have certain clinical application value.
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