Correlation Analysis of Elevated Lipoprotein(a)with the Severity of Coronary Artery Lesion in Premature Coronary Artery Disease
Objective To analysis the correlation between elevated lipoprotein(a)[Lp(a)]and severity of coronary artery lesion in patients with premature coronary artery disease(PCAD).Methods The clinical data of 457 patients admitted to the Xinhua Hospital,Shanghai Jiao Tong University School of Medicine from March 2020 to May 2021 with PCAD were collected,including general clinical data and coronary angiography results.All patients were divided into lower Gs group(Gs score＜26)and higher Gs group(Gs score ≥26)according to Gensini score(Gs),and the binary Logistic regression was used to analyze the correlation between elevated Lp(a)and lesion with higher Gs.Patients with elevated Lp(a)were divided into elevated Lp(a)group 1[Lp(a)≤50mg/dl]and elevated Lp(a)group 2[Lp(a)＞50mg/dl].Multivariate Logistic regression analysis was established to analyze the correlation between elevated Lp(a)and the risk of lesion with higher Gs.Results Compared with lower Gs group,the proportion of smokers,body mass index,and level of Lp(a)were higher than those in higher Gs group,while the the proportion of males and statin using,systolic blood pressure and diastolic blood pressure were lower than those in higher Gs group(P＜0.05).Multivariate Logistic regression analysis showed that elevated Lp(a)was significantly correlated with the occurrence of higher Gs lesions after adjusting for the influencing factors(OR=1.771,P＜0.05).Com-pared with the elevated Lp(a)group 1,the level of high-density lipoprotein was higher than that in elevated Lp(a)group 2(P＜0.05).Multivariate Logistic regression analysis showed that the risk of coronary higher Gs lesion in the elevated Lp(a)group 2 was 5.186 times higher than that in the elevated Lp(a)group 1 after adjusting for the influencing factors(P＜0.05).Conclusion Elevated Lp(a)is a risk factor for severe coronary artery lesion in patients with PCAD,which is positively correlated with level of Lp(a).
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