摘要
目的 探讨血清内脂素水平作为评估人体衰老程度的生物学标志物的潜力.方法 共招募 248 例年龄 25～90 岁的受试者,采用酶联免疫吸附试验测定血清内脂素水平,结合各项身体指标进行统计学分析.结果 Spearman 相关性分析结果显示,血清内脂素水平与年龄呈负相关(r =-0.186,P =0.003).将受试者按年龄分为 3 个区间,采用方差分析或秩和检验结果显示,年龄与血清内脂素水平、估算肾小球滤过率、胰岛素样生长因子 1、免疫球蛋白 M 呈负相关;与体重指数、腰臀比、全身脂肪质量、全身脂肪质量指数、D-3 羟基丁酸、游离脂肪酸、空腹血糖、胰岛素、胰岛素抵抗指数、胆碱酯酶、乳酸脱氢酶、谷丙转氨酶、谷草转氨酶、谷氨酰转肽酶、血清肌酐、血尿素氮、胱抑素 C、血清同型半胱氨酸呈正相关.将受试者按血清内脂素水平分为 3 个区间,采用方差分析或秩和检验结果显示,血清内脂素水平与血清同型半胱氨酸(P =0.001)呈负相关,与 IgM(P =0.013)呈正相关.结论 血清内脂素水平随年龄增加而降低,是一种潜在的衰老生物学标志物.
Abstract
Objective To explore the potential of serum visfatin level as a biomarker for evaluating the degree of human aging.Methods A total of 248 participants aged 25-90 years were recruited,and the serum visfatin levels were detected by enzyme linked im-munosorbent assay,and statistical analysis was performed combined with physical and biochemical indexes.Results The results of Spearman correlation analysis showed that serum visfatin levels were negatively correlated with age(r =-0.186,P =0.003).The partic-ipants were divided into three groups according to age.The results of ANOVA and rank-sum test showed that age was negatively correlated with serum visfatin levels,estimated glomerular filtration rate,insulin-like growth factor-1,IgM;positively correlated with body mass index,waist-to-hip ratio,body fat mass,body fat mass index,D-3hydroxybutyrate,free fatty acid,fasting blood glucose,insulin,HOMA-IR,cholinesterase,lactate dehydrogenase,alanine aminotransferase,aspartate aminotransferase,glutamyl transpeptidase,serum creatinine,blood urea nitrogen,cystatin C and serum homocysteine.The participants were divided into three groups according to serum visfatin levels.The results of ANOVA and rank-sum test showed that serum visfatin levels were negatively correlated with serum homocys-teine(P =0.001),positively correlated with IgM(P =0.013).Conclusion Serum visfatin levels decrease with age,which is a poten-tial aging biomarker.
基金项目
国家重点研发计划(2018YFC2000300)
国家自然科学基金(82073264)
深圳合成生物学创新研究院科研项目(DWKF20210009)
北京市东城区优秀人才培养项目(2022-dchrcpyzz-66)
NETL
NSTL
万方数据