Correlation Study of Serum Visfatin as Human Aging Biomarker
Objective To explore the potential of serum visfatin level as a biomarker for evaluating the degree of human aging.Methods A total of 248 participants aged 25-90 years were recruited,and the serum visfatin levels were detected by enzyme linked im-munosorbent assay,and statistical analysis was performed combined with physical and biochemical indexes.Results The results of Spearman correlation analysis showed that serum visfatin levels were negatively correlated with age(r =-0.186,P =0.003).The partic-ipants were divided into three groups according to age.The results of ANOVA and rank-sum test showed that age was negatively correlated with serum visfatin levels,estimated glomerular filtration rate,insulin-like growth factor-1,IgM;positively correlated with body mass index,waist-to-hip ratio,body fat mass,body fat mass index,D-3hydroxybutyrate,free fatty acid,fasting blood glucose,insulin,HOMA-IR,cholinesterase,lactate dehydrogenase,alanine aminotransferase,aspartate aminotransferase,glutamyl transpeptidase,serum creatinine,blood urea nitrogen,cystatin C and serum homocysteine.The participants were divided into three groups according to serum visfatin levels.The results of ANOVA and rank-sum test showed that serum visfatin levels were negatively correlated with serum homocys-teine(P =0.001),positively correlated with IgM(P =0.013).Conclusion Serum visfatin levels decrease with age,which is a poten-tial aging biomarker.
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