Expression and Clinical Significance of RAD54L in Liver Cirrhosis
Objective To explore the expression of RAD54 - like protein (RAD54L) in liver cirrhosis and its clinical significance. Methods The expression of RAD54L was analyzed by bioinformatics and verified by clinical specimens and mouse cirrhosis model. Correlation analysis was performed between RAD54L level and liver function of serum specimens to explore the clinical significance of RAD54L. Results As a key gene for homologous recombination repair, RAD54L expression difference was verified by liver cirrhosis database (P < 0. 05). RAD54L was increased in both clinical specimens (P < 0. 01) and mouse model specimens (P < 0. 01). RAD54L was positively correlated with liver function indexes (alanine aminotransferase, aspartate aminotransferase), which reflected the degree of liver injury to a certain extent. Conclusion RAD54L can be used as a molecular marker to determine liver injury and its progression.
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