Mendelian Randomization Study of Interleukin-1 Receptor Antagonists and Osteoarthritis and Subtypes
Objective To assess the causal relationship between interleukin-1 receptor antagonist(IL-1RA)and osteoarthritis and subtypes of osteoarthritis by two-sample Mendelian randomization study.Methods Single nucleotide polymorphism(SNP)for IL-1RA and osteoarthritis,knee osteoarthritis,and hip osteoarthritis were obtained from a publicly available genome-wide association study pooled dataset,and closely related SNP were selected as instrumental variable(IV).Screening sensitivity tests,MR multiplicity residuals and outlier testswere used to validate the heterogeneity and multiplicity of the identified IV.Five different models,including inverse-vari-ance weighted(IVW),weighted median estimation model,weighted model-based approach,MR-Egger regression and simple plurality method were used for MR analysis.Results There was no heterogeneity in the study.IVW of fixed-effect models showed that there were significant causal relationships between IL-1RA and osteoarthritis(OR = 1.06,95%CI:1.01-1.11),knee osteoarthritis(OR = 1.07,95%CI:1.01-1.13),and a correlation with hip osteoarthritis,with a non-significant causal relationship.Sensitivity a-nalysis showed that the study results were robustness.Conclusion The MR study supports a causal relationship between IL-1RA levels and the risk of developing osteoarthritis and knee osteoarthritis.
Interleukin-1 receptor antagonistOsteoarthritisMendelian randomization study
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