Difference and Correlation Analysis of Free Testosterone Index and Clinical Characteristics in Polycystic Ovary Syndrome Patients with Phlegm-dampness Syndrome
Objective To investigate the difference and correlation between free testosterone index(FAI)and different clinical characteristics in patients with polycystic ovary syndrome(PCOS)with phlegm-dampness syndrome and non-phlegm-dampness syn-drome.Methods Based on the case data collected from the clinical research information integration platform,1041 PCOS patients who visited the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from September 2019 to January 2021 were retrospec-tively included.According to the diagnostic criteria of traditional Chinese medicine(TCM),they were divided into phlegm-dampness syndrome group(n =658)and non-phlegm-dampnesssyndrome group(n =383).All the indicators were recorded and the correlation between each indicator and FAI was statistically analyzed to analyze the influencing factors of FAI of different TCM syndrome types.Results The values of FAI,body weight,waist circumference,hip circumference,waist-to-hip ratio(WHR),fasting plasma glucose(FPG),30-minute glucose,fasting insulin(FINS),30-minute insulin,insulin resistance of homeostasis model assessment(HOMA-IR),triglyceride(TG),total cholesterol(TC),low-density lipoprotein-cholesterol(LDL-C),apolipoprotein B(ApoB),ApoB/ApoA in PCOS patients with phlegm-dampness syndrome were higher than those in non-phlegm-dampness syndrome group(P<0.05).In PCOS patients in the phlegm-dampness syndrome group,FAI was negatively correlated with follicle-producing hormone(FSH),prolactin(PRL),sex hormone-binding globulin(SHBG),high-density lipoprotein-cholesterol(HDL-C)and apolipoprotein A(ApoA);FAI was positively correlated with systolic blood pressure,diastolic blood pressure,body weight,body mass index(BMI),waist circumference,hip circumference,WHR,testosterone(T),androstenedione(AND),60-minute glucose,120-minute-glucose,FINS,30-minute insulin,60-minute insulin,120-minute insulin,180-minute insulin,HOMA-IR index,TG,ApoB/ApoA(P<0.05).In PCOS patients in the non-phlegm-dampness syndrome group,FAI was negatively correlated with PRL and SHBG.FAI was positively correlated with diastolic blood pressure,body weight,BMI,waist circumference,T,dehydroepiandrosterone sulfate(DHEAS),AND,60-minute glucose,120-minute glucose,FINS,60-minute insulin,120-minute insulin,180-minute in-sulin,ApoB,HOMA-IR index(P<0.05).Conclusion There are significant differences in the levels of FAI and other research indi-cators in PCOS patients between phlegm-dampness syndrome and the non-phlegm-dampness syndrome.The FAI level of PCOS pa-tients with phlegm-dampness syndrome is higher than that of the non-phlegm-dampness syndrome.The level of FAI in PCOS patients with phlegm-dampness syndrome is significantly correlated with obesity,glucose and lipid metabolism,and its causality needs to be fur-ther explored.
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