Relationship between Serum Ferritin and Prognosis in Patients with Severe Diabetic Kidney Disease Based on MIMIC-Ⅳ Database
Objective To investigate the relationship between serum ferritin(SF)and prognosis in patients with severe diabetic kid-ney disease(DKD).Methods The clinical data of severe DKD patients in the MIMIC-Ⅳ database were analyzed retrospectively.Ac-cording to the survival condition at 60days after admission,the patients with severe DKD were divided into survival group(n = 87)and death group(n =659).According to the SF level at 60days after admission,the patients with severe DKD were divided into low SF group(SF≤333ng/ml,n =373)and high SF group(SF>333ng/ml,n = 373).The Kaplan-Meier curve was used to compare the survival rates of severe DKD patients with different SF levels,and multivariate COX regression analysis was used to evaluate the risk factors for 60-day all-cause death in severe DKD patients.Results A total of 746 patients with severe DKD were included,and the 60-day all-cause mortality rate was 11.6%.The values of age,white blood cell count,red blood cell distribution width,creatinine,blood urea nitrogen,urine protein,SF,acute kidney injury,and continuous renal replacement therapy in the death group were higher than those in the survival group,while the systolic blood pressure,diastolic blood pressure,hemoglobin,and transferrin were lower than those in the survival group.Kaplan-Meier curve analysis showed that the 60-day survival rate of high SF group was significantly lower than that of low SF group(χ2 =12.163,P<0.001).Multivariate COX regression analysis showed that high SF(HR =1.0001,95%CI:1.0001-1.0002)was an independent risk factor for 60-day all-cause death in patients with severe DKD(P<0.05).Conclusion High level of SF level is an independent risk factor for 60-day all-cause death in patients with severe DKD.
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