Systematic Review of the Efficacy and Safety of Wenxinkeli in the Treatment of Depression or Anxiety
Objective To evaluate the efficacy and safety of Wenxinkeli in the treatment of depression or anxiety.Methods Seven databases of China Biology Medicine(CBM),CNKI,WIP,Wanfang,PubMed,Web of Science,and Cochrane were systematically searched,randomized controlled trials(RCTs)were screened according to the inclusion and exclusion criteria,and risk assessment tools were used to evaluate research quality.The data were extracted,and Revman 5.4.1 and Stata 14 were used for Meta-analysis.Results A total of 9 RCTs including 723 patients were included.Among them,2 RCTs were Wenxinkeli versus antidepressants,and 7 RCTs were Wenxinkeli combined with antidepressants versus antidepressants.The results of the Meta-analysis showed that:compared with the use of antidepressants,Wenxinkeli were significant in reducing the Hamilton depression scale(HAMD)score(MD =-3.53,95%CI:-4.71--2.31,P<0.001);the combination of Wenxinkeli with antidepressants was significant in reducing Hamilton anxiety scale(HAMA)score(MD =-3.52,95%CI:-5.46--1.57,P<0.001),HAMD score(MD =-3.42,95%CI:-4.66--2.18,P<0.001),and there was no significant difference in treatment emergent symptom scale(TESS)score(MD =-0.78,95%CI:-1.64-0.07,P =0.07).The effectiveness rate of Wenxinkeli combined with antidepressants was better than that of the antidepressant group in terms of HAMA reduction rate(RR =1.31,95%CI:1.13-1.51,P<0.001)and HAMD reduction rate(RR =1.10,95%CI:1.04-1.17,P<0.001).Conclusion Wenxinkeli are more effective in relieving depression than antidepressants,and the use of Wenxinkeli combined with antidepressants is more effective than antidepressants in treating the depression or anxiety without significant ad-verse effects.
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