Clinical Characteristics and Influencing Factors of Severe Pertussis in Children
Objective To explore the clinical characteristics of children with severe pertussis and the influencing factors for the de-velopment of severe pertussis.Methods The demographic data and clinical data of children with pertussis admitted to the Children's Hospital,Capital Institute of Pediatrics between March 2011 and December 2018 were collected retrospectively.The patients were divided into two groups according to the severity of pertussis:severe pertussis group and non-severe pertussis group.The relevant indexes were compared between the two groups,and the influencing factors of severe pertussis were discussed.Results Among 227 children with per-tussis,54(23.8%)were in the severe pertussis group,and 173 cases(76.2%)were in the non-severe pertussis group.The mean on-set age of severe pertussis group was significantly lower that in the non-severe pertussis group[1.35(0.60,2.36)months vs 3.93(1.19,7.67)months,P<0.01].The incidence of the paroxysmal spasmodic cough,post-tussive vomiting,paroxysmal cyanosis,fa-cial flushing during coughing,and fever were higher in the severe pertussis group than that in the non-severe pertussis group,and the differences were statistically significant(96.3%vs 81.5%,31.5%vs 13.9%,81.5%vs 9.8%,98.2%vs 76.9%and 51.9%vs 27.2%,P<0.05).The complete-vaccination proportion was significantly lower in the severe pertussis group than that in the non-se-vere pertussis group(1.9%vs 19.1%,P<0.01).The non-vaccination proportion was significantly higher in the severe pertussis group than that in the non-severe pertussis group(94.4%vs 69.4%,P<0.01).The results of Logistic regression analysis showed that complete-vaccination was a protective factor for diminishing the development of severe pertussis(OR =0.07,95%CI:0.008-0.610,P =0.02).Conclusion Infants<3months of age are prone to severe pertussis,and the younger the infant,the more severe pertussis.Complete-vaccination was a protective factor for diminishing the development of severe pertussis in children.
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