Analysis of CAPN3 Expression,Prognosis and Immune Infiltration in Ovarian Serous Cystadenocarcinoma
Objective To study the expression level of CAPN3 in ovarian serous cystadenocarcinoma,and to clarify its relationship with the prognosis and immune infiltration of ovarian serous cystadenocarcinoma.Methods GEPIA2,TIMER,TISIDB and Kaplan-Meier plotter were used to analyze the expression profile,immune infiltration and prognostic value of CAPN3 in ovarian serous cystadeno-carcinoma.Then,the STRING database was used to construct the protein-protein interaction(PPI)network involving CAPN3,and the GEPIA database was used to analyze the correlation between 10genes and CAPN3.Results The expression of CAPN3 was low in patients with ovarian serous cystadenocarcinoma.With the deterioration of ovarian serous cystadenocarcinoma,the expression of CAPN3 was de-creased.The expression level of CAPN3 was significantly correlated with most of the immune markers in ovarian serous cystadenocarcino-ma,including CD16,STAT5A,STAT3,LAG-3 and so on.In addition,CAPN3 was significantly correlated with four immunosuppressa-nts(BTLA,CD274,CSF1R and LGALS9)and seven immunostimulators(CD276,CXCL12,HHLA2,IL-6,TMEM173,TNFSF13 and ULBP1).High expression of CAPN3 mRNA in patients with ovarian serous cystadenocarcinoma showed better overall survival,but not significantly in progression-free survival.The analysis of the regulatory network showed that TTN was most significantly correlated with CAPN3.Conclusion CAPN3 gene may be a tumor marker for predicting the occurrence,development and prognosis of ovarian se-rous cystadenocarcinoma.
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