SII Combined with hs-CRP Predict the Risk of Pancreatitis after Endoscopic Retrograde Cholangiopancreatography
Objective To investigate the relationship between the development of postoperative pancreatitis(PEP)and systemic im-mune inflammatory index(SII)and high-sensitivity C-reactive protein(hs-CRP)levels in patients treated with endoscopic retrograde cholangiopancreatography(ERCP),and to further analyze the predictive value of SII combined with hs-CRP for PEP.Methods The clinical data of patients treated with ERCP in the First Clinical College of Xuzhou Medical University from January 2021 to December 2022 were retrospectively analyzed.Restricted cubic spline(RCS)were used to determine the correlation between SII and hs-CRP and the risk of PEP.Multivariate Logistic regression was used to analyze the factors affecting PEP.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of SII,hs-CRP and their combination levels for PEP.Results RCS analysis showed that SII>669.06×109/L and hsCRP>13.94mg/dl were positively correlated with the incidence of PEP.The incidence of PEP increased with the development of inflammatory state.The area under the ROC curve of SII combined with hs-CRP was 0.819,which was higher than that of SII or hsCRP alone.Multivariate Logistic regression analysis showed that female,maximum diameter of large choledochal stones,serum amylase 3h after surgery,and elevation of SII and hsCRP levels were the risk factors for PEP.Conclusion Within a certain range,ele-vated inflammatorymarkers SII and hs-CRP are the risk factors for the development of PEP after ERCP.The combination of SII and hs-CRP was more accurate in predicting the risk of PEP than either biomarker alone.
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