Effect of Botulinum Toxin A Combined with Exercise Program Sit-to-stand Training on Lower Limb Spasticity and Balance Ability in Pa-tients with Stroke
Objective To observe the effect of botulinum toxin A combined with exercise program sit-to-stand training on lower limb spasticity and balance ability in patients with stroke.Methods A total of 84 patients with stroke admitted to our hospital from Janu-ary 2020 to December 2021 were randomly divided into control group(n=42)and treatment group(n=42).The control group was trea-ted with the exercise program sit-to-stand training alone.The treatment group was treated with botulinum toxin A combined with exer-cise program start-up training.The modified Ashworth scale(MAS),Fugl-Meyer assessment(FMA),Berg balance scale(BBS),Barthel index(BI),and stroke-specific quality of life(SS-QOL)were compared between the two groups before treatment,and 4,8,and 12 weeks after treatment.Results No significant difference in clinical baseline data was found between the two groups(P＞0.05).The MAS of the two groups at 4,8 and 12 weeks after treatment was significantly lower,while the FMA,BBS,BI,and SS-QOL were significantly higher than those before treatment(P＜0.05).Compared with the control group,the improvement of MAS,FMA,BBS,BI,and SS-QOL at 4,8 and 12 weeks after treatment was better than those in the control group(P＜0.05).Conclusion Botulinum toxin A combined with exercise program sit-to-stand training can significantly alleviate lower limb spasticity in patients with stroke,improve motor function and balance ability,and improve the ability of daily life and quality of life,which is worthy of clinical promotion and appli-cation.
Botulinum toxin AExercise program sit-to-stand trainingStrokeSpasticity
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