Serum Metrnl Level and Its Predictive Value in Patients with Type 2 Diabetes Mellitus Complicated with Non-alcoholic Fatty Liver Disease
Objective To observe the level of serum Meteorin-like protein(Metrnl)in patients with type 2diabetes mellitus(T2DM)complicated with non-alcoholic fatty liver disease(NAFLD).To explore the predictive value of serum Metrnl for the occur-rence of NAFLD in T2DM patients.Methods From January 2022 to June 2023,218 patients with T2DM were initially diagnosed in the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University(Xuzhou First People's Hospital).According to whether NAFLD was combined,they were divided into T2DM group(n=105)and T2DM combined with NAFLD group(n=113).The general information,related biochemical and metabolic indicators of the two groups of patients were collected,and the serum Metrnl levels of the two groups were detected by enzyme-linked immunosorbent assay(ELISA).Results Homeostasis model assessment insulin resistance index(HO-MA-IR),glycosylated hemoglobin(HbA1c)and triglyceride(TG)in T2DM combined with NAFLD group were higher than those in T2DM group,while high-density lipoprotein cholesterol(HDL-C)and Metrnl were lower than those in T2DM group,and the differ-ences were statistically significant(P＜0.05).Logistic regression results showed that body mass index(BMI)and TG were risk factors for T2DM with NAFLD(OR＞1,P＜0.05),HDL-C and Metrnl were protective factors for T2DM with NAFLD(OR＜1,P＜0.05).Spearman correlation analysis showed that Metrnl was negatively correlated with TG,HbA1c,HOMA-IR and BMI in initially diagnosed T2DM patients(r＜0,P＜0.05),and positively correlated with HDL-C(r＞0,P＜0.05).Receiver operating characteristic(ROC)curve analysis show that,the area under the curve(AUC)of BMI,TG,HDL-C and Metrnl predicting T2DM combined with NAFLD was 0.719,0.701,0.736 and 0.771.The AUC of Metrnl was largest.Conclusion The serum Metrnl levels in initially diagnosed T2DM combined with NAFLD patients are lower than those in simple T2DM patients,and serum Metrnl levels has good predictive power for the presence of NAFLD in initially diagnosed T2DM patients.
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