Prognostic Value of AGR for Prognosis in Patients with First-line Chemotherapy for Stage Ⅲ-Ⅳ Non-small Cell Lung Cancer
Objective To explore the prognostic value of albumin/globulin(AGR)in patients with stage Ⅲ-Ⅳ non-small cell lung cancer(NSCLC)treated with first-line chemotherapy.Methods From January 2016 to December 2020,288 patients with ad-vanced NSCLC initially diagnosed in the Affiliated Hospital of Xuzhou Medical University were selected.AGR critical value was deter-mined by receiver operating characteristic(ROC)curve,patients were divided into high AGR group(n=104)and low AGR group(n=184).Survival curve was plotted using Kaplan-Meier method,overall survival(OS)and progression-free survival(PFS)were com-pared between the two groups.COX proportional risk regression model was used to analyze the factors affecting prognosis of NSCLC pa-tients.Results The critical value of AGR was 1.5,the area under the curve of AGR was 0.693,the sensitivity was 76.8％,and the specificity was 58.3％.AGR was correlated with age,pathological type and curative effect(P＜0.05).The high AGR group had longer PFS and OS than the low AGR group(9 months vs 5months,25months vs 19months).Multivariate COX regression analysis showed that low level of AGR was an independent risk factor for NSCLC patients(P＜0.05).Conclusion AGR can be used as an effective prognos-tic indicator for patients with stage Ⅲ-Ⅳ NSCLC treated with first-line chemotherapy,and low levels of AGR suggest poor prognosis.
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