Correlation of Ceramide and Intracranial and Extracranial Atherosclerotic Stenosis in Elderly Patients with Ischemic Stroke
Objective To investigate the valuation of ceramide(Cer),trigly ceride-glucose index(TyG index)and residual cho-lesterol(RC)levels on intracranial and extracranial atherosclerotic stenosis in elderly patients with ischemic stroke(IS).Methods A total of 447 elderly patients with IS who were hospitalized in the Affiliated Hospital of Xuzhou Medical University from January 2022 to June 2023 were selected.According to the digital subtraction angiography(DSA)results,the patients were divided into non-stenosis group(n=144)and stenosis group(n=303).The stenosis group was further divided into moderate stenosis group(n=121),severe stenosis and occlusion group(n=182).The general information and baseline biochemical data of all patients were collected.High per-formance liquid chromatography tandem mass spectrometry was used to detect serum Cer,and TyG index and RC level were calculated.Spearman method was used to analyze the correlation between Cer,TyG index,RC and intracranial and extracranial atherosclerotic steno-sis.Multivariate Logistic regression was used to analyze the risk factors of intracranial and extracranial atherosclerotic stenosis.Results Compared with the non-stenosis group,Cer,TyG index,RC,Lp(a),and glycosylated hemoglobin(HbA1c)and other indexes were significantly increased in the stenosis group(P＜0.05).Multivariate Logistic regression analysis showed that Cer16:0,Cer18:0,Cer24:1,Cer24:1/Cer24:0,Cer18:0/Cer24:0,Cer16:0/Cer24:0 were independent risk factors for intracranial and extracranial atherosclerotic stenosis in elderly patients with IS.Spearman correlation analysis showed that Cer24 was negatively correlated with intracranial and ex-tracranial atherosclerotic stenosis(r=-0.122,P＜0.05).The results of receiver operating characteristic curve showed that,the areas under the curve of Cer24:1,Cer24:1/Cer24:0,Cer18:0/Cer24:0,Cer16:0/Cer24:0,RC,TyG index in the diagnosis of intracranial and extracranial atherosclerotic stenosis in elderly patients with IS were 0.832,0.846,0.826,0.829,0.578,0.586(P＜0.05).Conclusion The serum levels of serum Cer,TyG index and RC are higher in elderly patients with IS,which may be the risk factors for intracranial and extracranial atherosclerotic stenosis in elderly patients with IS.
CeramideIschemic strokeTriglyceride-glucose indexResidual cholesterolIntracranial and extracranial athero-sclerotic stenosis
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