Predictive Value of CRP/Alb Ratio on Early Small or Medium-sized Coronary Artery Aneurysm of Children with Kawasaki Disease
Objective To investigate the predictive value of C-reactive protein/albumin(CRP/Alb)ratio on early small or medi-um-sized coronary artery aneurysm(CAA)of children with Kawasaki disease(KD).Methods The clinical data of 116 children with KD admitted to the First Affiliated Hospital of Xinxiang Medical University from September 2018 to December 2021 were retrospectively analyzed,and they were divided into CAA group(n=34)and non-CAA group(n=82).The general conditions,clinical characteris-tics and laboratory indicators were compared between the two groups.Univariate analysis was used to screen the related factors of early small or medium-sized CAA of children with KD,and multivariate Logistic regression analysis was used to estimate the independent risk factors of early small or medium-sized CAA of children with KD.Then the receiver operating characteristic(ROC)curve was plotted to evaluate the predictive value of CRP/Alb ratio on early small or medium-sized CAA of children with KD.Results Univariate analysis showed that compared with the non-CAA group,the proportion of males in CAA group was higher,the incidence of pleomorphic rash was higher,CRP,fibrinogen and CRP/Alb ratio were significantly increased,and the differences were statistically significant(P＜0.05).The multivariate logistic regression analysis showed that male,fibrinogen and CRP/Alb ratio were the independent risk factors for early small or medium-sized CAA of children with KD.The ROC curve analysis showed that CRP/Alb ratio had a good predictive value for early small or medium-sized CAA of children with KD,with the best cut-off value of 1.4,with sensitivity of 82％,specificity of 66％,and the area under the ROC curve of 0.811.Conclusion CRP/Alb ratio can be used as a marker of predict the early small or medium-sized CAA of children with KD.
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