C反应蛋白与白蛋白比值对川崎病患儿早期合并中小型冠状动脉瘤的预测价值
Predictive Value of CRP/Alb Ratio on Early Small or Medium-sized Coronary Artery Aneurysm of Children with Kawasaki Disease
王远飞 1王蓓蓓 2田运娇 1李培岭 1赵东菊 1马岩岩1
作者信息
- 1. 453100 新乡医学院第一附属医院儿科
- 2. 453000 新乡医学院第三附属医院消化内科
- 折叠
摘要
目的 探讨C反应蛋白(C-reactive protein,CRP)与白蛋白(albumin,Alb)比值(CRP/Alb)对川崎病(Kawasaki dis-ease,KD)患儿早期合并中小型冠状动脉瘤(coronary artery aneurysm,CAA)的预测价值.方法 回顾性分析2018年9月～2021年12月新乡医学院第一附属医院收治的116例KD患儿的临床资料,将其分为CAA组(n=34)及无CAA组(n=82).比较两组患儿的一般情况、临床表现、实验室指标,采用单因素分析筛选KD患儿早期合并中小型CAA的相关因素,多因素Logistic回归分析评价KD患儿早期合并中小型CAA的独立危险因素,并绘制受试者工作特征(receiver operating characteristic,ROC)曲线,评估CRP/Alb比值对KD患儿早期合并中小型CAA的预测价值.结果 单因素分析结果显示,与无CAA组比较,CAA组男童所占比例更高,多形性皮疹发生率更高,CRP、纤维蛋白原及CRP/Alb比值均明显增高,差异均有统计学意义(P＜0.05).多因素Logis-tic 回归分析结果显示,男童、纤维蛋白原、CRP/Alb比值是预测KD患儿早期合并中小型CAA的独立危险因素(P＜0.05).ROC曲线分析结果显示,CRP/Alb比值对KD患儿早期合并中小型CAA具有很好的预测价值,最佳截断值为1.4,其敏感度为82％,特异性为66％,曲线下面积为0.811.结论 CRP/Alb比值可作为预测KD患儿早期合并中小型CAA的标志物之一.
Abstract
Objective To investigate the predictive value of C-reactive protein/albumin(CRP/Alb)ratio on early small or medi-um-sized coronary artery aneurysm(CAA)of children with Kawasaki disease(KD).Methods The clinical data of 116 children with KD admitted to the First Affiliated Hospital of Xinxiang Medical University from September 2018 to December 2021 were retrospectively analyzed,and they were divided into CAA group(n=34)and non-CAA group(n=82).The general conditions,clinical characteris-tics and laboratory indicators were compared between the two groups.Univariate analysis was used to screen the related factors of early small or medium-sized CAA of children with KD,and multivariate Logistic regression analysis was used to estimate the independent risk factors of early small or medium-sized CAA of children with KD.Then the receiver operating characteristic(ROC)curve was plotted to evaluate the predictive value of CRP/Alb ratio on early small or medium-sized CAA of children with KD.Results Univariate analysis showed that compared with the non-CAA group,the proportion of males in CAA group was higher,the incidence of pleomorphic rash was higher,CRP,fibrinogen and CRP/Alb ratio were significantly increased,and the differences were statistically significant(P＜0.05).The multivariate logistic regression analysis showed that male,fibrinogen and CRP/Alb ratio were the independent risk factors for early small or medium-sized CAA of children with KD.The ROC curve analysis showed that CRP/Alb ratio had a good predictive value for early small or medium-sized CAA of children with KD,with the best cut-off value of 1.4,with sensitivity of 82％,specificity of 66％,and the area under the ROC curve of 0.811.Conclusion CRP/Alb ratio can be used as a marker of predict the early small or medium-sized CAA of children with KD.
关键词
川崎病/冠状动脉瘤/C反应蛋白与白蛋白比值/预测/儿童Key words
Kawasaki disease/Coronary artery aneurysm/CRP/Alb ratio/Prediction/Children引用本文复制引用
基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20210506)
出版年
2024
NETL
NSTL
万方数据