超高分辨率超声测量兔颈动脉粥样硬化斑块内新生血管的应用价值
Application of Rabbit Carotid Atherosclerotic Plaque Neovascularization using Ultrasound Localization Microscopy
任俊奕 1白文坤 1郑元义1
作者信息
- 1. 200233 上海交通大学医学院附属第六人民医院超声科
- 折叠
摘要
目的 探讨超高分辨率超声(ultrasound localization microscopy,ULM)技术测量兔颈动脉粥样硬化斑块内新生血管参数与病理结果的相关性.方法 使用球囊损伤联合高脂饮食建立兔颈动脉粥样硬化易损斑块模型,利用SRUS技术测量斑块内新生血管,定量新生血管密度、直径、扭曲度、速度参数,并与病理学结果进行比较,评估SRUS技术检测及测量斑块内新生血管参数方面的可靠性.结果 SRUS技术可以对兔颈动脉粥样硬化易损斑块内的新生血管进行超高分辨率成像,同时可以准确测量斑块内新生血管的密度.与病理学诊断的相关性较好(r=0.915,P＜0.05).结论 SRUS技术检测兔颈动脉粥样硬化斑块内新生血管具有一定的可靠性.
Abstract
Objective To investigate the correlation between intraplaque neovascularization(IPN)parameters using ultrasound lo-calization microscopy(ULM)and pathological results.Methods Atherosclerosis of the carotid artery in rabbit was induced using balloon catheter damage and a high-cholesterol diet.ULM technology was used to measure the IPN,and the parameters of neovascularization density,diameter,distortion and velocity were quantified,and compared with pathological results,to evaluate the reliability of ULM tech-nique in detecting and measuring the parameters of IPN.Results ULM technology can perform ultra-high resolution imaging of the IPN in rabbit carotid atherosclerotic plaques,and can accurately measured the density of IPN.The correlation with pathological diagnosis was good(r=0.915,P＜0.05).Conclusion ULM technique has a certain reliability in detecting the IPN in rabbit carotid atherosclerotic plaque.
关键词
斑块内新生血管/超高分辨率超声/人工智能Key words
Intraplaque neovascularization/Ultrasound localization microscopy/Artificial intelligence引用本文复制引用
出版年
2024
NETL
NSTL
万方数据