Prognostic Value of Adrenocorticotropic Hormone in Patients with Newly Diagnosed Acute Myeloid Leukemia
Objective To explore the clinical characteristics and prognostic significance of adrenocorticotropic hormone(ACTH)level in patients with acute myeloid leukemia(AML).Methods A total of 235 AML patients were enrolled from January 2015 to October 2021.The survival curves between ACTH groups were drawn by Kaplan-Meier.The risk factors of overall survival(OS)were analyzed by COX regression analysis.The prognostic model was constructed by R software and verified by calibration curve.Results Among 235 AML patients,the ACTH level of 40 patients were lower than 7.2pg/ml.Kaplan-Meier survival curve analysis indicated that the survival time of patients with low ACTH was significantly shortened.Univariate analysis showed that age,prognosis classification of European Leu-kemia Net(ELN),Eastern Cooperative Oncology Group(ECOG)score,and ACTH were correlated with poor survival in AML patients(P＜0.05).Multivariate COX regression analysis showed that age,prognosis classification of ELN,ECOG score,and ACTH level were the independent factors for patient survival(P＜0.05).A nomogram and calibration curves for predicting overall survival were construc-ted using these factors,which showed that the calibration curve of the model was close to the standard curve,showing a good linear rela-tionship.Conclusion Low ACTH level is an independent prognostic factor for survival in AML patients,and a model of nomogram con-structed based on age,prognostic classification of ELN,ECOG score and ACTH level has a good predictive value.
Adrenocorticotropic hormoneAcute myeloid leukemiaRisk factorsNomogram model
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NSTL
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