目的 探讨非特殊型浸润性乳腺癌(invasive breast carcinoma of no specific type,IBC-NST)边缘带二维超声特征、超声造影增强特征及定量参数与Ki-67的相关性.方法 收集2019年10月～2023年10月在山西医科大学第一医院经手术病理及免疫组化证实的IBC-NST患者84例(84个单侧单发病灶),年龄25～78岁,所有患者术前均未进行放化疗,且均行二维超声、超声造影检查.根据Ki-67表达程度将其分为高表达组和低表达组,分析对比两组病灶边缘带二维超声特征、超声造影增强特征及定量参数,分析定量参数与Ki-67的相关性.结果 Ki-67高表达组IBC-NST患者病灶边缘带边界模糊比例高于Ki-67低表达组,差异均有统计学意义(P＜0.05).Ki-67高表达组IBC-NST患者病灶边缘带增强特征、边缘放射状增强、造影后范围扩大比例均高于Ki-67低表达组,差异均有统计学意义(P＜0.05).Ki-67高表达组IBC-NST患者病灶边缘带超声造影定量参数峰值强度(peak intensity,PI)、曲线下面积(area under the curve,AUC)均高于Ki-67低表达组,差异均有统计学意义(P＜0.05).IBC-NST边缘带定量参数PI、AUC与Ki-67表达呈正相关,差异均有统计学意义(P＜0.05).结论 IBC-NST患者病灶边缘带边界模糊、边缘放射状增强、造影后范围扩大、定量参数PI、AUC升高可提示Ki-67高表达,为临床个体化精准治疗提供了一定的影像学指导.
Correlation Analysis of Marginal Zone Enhancement Features and Quantitative Parameters of Contrast-enhanced Ultrasound with Ki-67 in Invasive Breast Carcinoma of No Specific Type
Objective To explore the correlation between marginal zone two-dimensional ultrasound features,enhancement fea-tures and quantitative parameters of contrast-enhanced ultrasound and Ki-67 in the invasive breast carcinoma of no specific type(IBC-NST).Methods From October 2019 to October 2023,84 patients with IBC-NST(84 unilateral lesions),aged 25 to 78 years,confirmed by surgical pathology and immunohistochemistry were collected from the First Hospital of Shanxi Medical University.All patients had not received preoperative chemoradiotherapy,and underwented two-dimensional ultrasound and contrast-enhanced ultrasound exam-ination.They were divided into high expression group and low expression group according to the expression degree of Ki-67.The two-dimensional ultrasound features and contrast-enhanced ultrasound features and quantitative parameters of two groups were analyzed and compared,and their correlation between the quantitative parameters and Ki-67 was analyzed.Results The proportion of margin indis-tinct of IBC-NST lesion in Ki-67 high expression group was higher than that in Ki-67 low expression group,and the differences were statistically significant(P＜0.05).The proportion of adial enhancemen and the range enlargement after angiography of IBC-NST lesion in Ki-67 high expression group was higher than those in Ki-67 low expression group,and the differences were statistically significance(P＜0.05).The quantitative parameters peak intensity(PI),area under the curve(AUC)of IBC-NST lesion in Ki-67 high expres-sion group were higher than those in Ki-67 low expression group,and the differences were statistically significant(P＜0.05).IBC-NST marginal zone quantitative parameters PI,AUC were positively correlated with Ki-67 expression,and the differences were statistical-ly significant(P＜0.05).Conclusion In patients with IBC-NST,the marginal zone of the lesion is margin indistinct,the radial en-hancement,the srange enlargement after angiography,and the quantitative parameters PI,AUC are increased,indicating the high expres-sion of Ki-67,providing certain imaging guidance for clinical individualized precision treatment.
Invasive breast carcinoma of no specific typeContrast-enhanced ultrasoundMarginal zoneKi-67
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