Effects of Different Antibody Types of Hp Infection on the Serum Gastric Function in Chronic Atrophic Gastritis
Objective To detect the expression of serum gastric function in patients with chronic atrophic gastritis(CAG)and de-termine the effect of Hp infection with different antibody types on serum gastric function in CAG.Methods The patients in outpatient de-partment of Affiliated Hospital of Xuzhou Medical University were selected for gastric examination and divided into two groups:chronic non-atrophic gastritis(CNAG)group and CAG group.The serum levels of gastric function expression were detected using fluorescence immunochromatography,and the Hp antibody type was determined by Western blot,to analyze the effects of different Hp antibody types on the gastric function of CAG serum.Results Compared with the CNAG group,the G17 level in the CAG group was significantly in-creased.The proportion of Ure-positive individuals,Ure-positive+CagA-positive individuals,and Ure-positive+CagA-positive+VacA-positive individuals in the CAG group showed a significant increase(P=0.017).In the Hp-negative group,the expression level of G17 in the CAG group was higher than that in the CNAG group(P=0.024),and the expression level of PG Ⅱ in Ure-positive+Ca-gA-positive individuals was lower than that in CNAG group(P=0.019).In the CAG group,the PGR(PG I/PG Ⅱ)of Ure-positive+VacA-positive and Ure-positive+CagA-positive+VacA-positive individuals was lower than that of Ure-positive+CagA-posi-tive individuals(P＜0.05).In addition,PG I levels were lower in moderate and severe atrophy groups compared to mild atrophy groups within the CAG group(P＜0.001),and PGR levels were also lower in moderate and severe atrophy groups compared to mild atrophy groups(P＜0.001).Furthermore,proportions of Ure-positive+CagA-positive,Ure-positive+VacA-positive,and Ure-positive+CagA-positive+VacA-positive individuals were higher in moderate and severe atrophy groups compared to mild atrophy groups(P=0.013).Conclusion The level of G17 was increased in the CAG group,and Hp infection with different types of antibodies affected the occurrence and severity of CAG atrophy.VacA-positive+Hp infection(with or without CagA-positive)resulted in a lower PGR in patients with CAG,while CagA-positive+Hp infection alone resulted in a higher PGR in patients with CAG.
Antibody typingHpChronic atrophic gastritisSerum gastric function
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