Influencing Factors of Seizures in Early Pregnancy
Objective To investigate the related influencing factors of seizures in early pregnancy.Methods Patients with epilepsy and pregnancy in Suzhou Hospital Affiliated to Nanjing Medical University from July 2019 to July 2023 were retrospectively enrolled and divided into epileptic group(n=35)and non-epileptic group(n=48)according to whether they had epilepsy in early pregnancy.Uni-variate and multivariate Logistic regression models were used to analyze the influencing factors of seizures in early pregnancy.And the re-ceiver operating characteristic(ROC)curve was further used to evaluate the predictive efficiency of the relevant models.Results Univa-riate analysis showed that there were statistically significant differences in the occurrence of seizures,frequency of seizures in 9months be-fore pregnancy and whether adjusted treatment plan after pregnancy between epileptic group and non-epileptic group(P＜0.05).Multi-variate Logistic regression analysis showed that the occurrence of seizures,the frequency of seizures in 9months before pregnancy,and the whether adjusted treatment plan after pregnancy were correlated with seizures in early pregnancy(P＜0.05).The area under the ROC curve of the predicted model was 0.750(95％CI:0.652-0.858)based on the results of multivariate Logistic regression analysis.Conclusion The occurrence of seizures,the frequency of seizures in 9months before pregnancy and whether adjusted treatment plan after pregnancy are related to the onset of seizures in early pregnancy.The prediction model established according to the results of multivariate Logistic regression analysis has some predictive value.
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