Impact of Triglyceride Glucose Index during Early Pregnancy on Glucose and Lipid Metabolism in Gestational Diabetes Mellitus
Objective To investigate the impact of triglyceride glucose index(TyG index)during early pregnancy on glucose and lipid metabolism in gestational diabetes mellitus.Methods A total of 527 pregnant women with gestational diabetes mellitus who deliv-ered at the Huizhou First Maternal and Child Health Care Hospital from May 2021 to August 2022 were selected.Based on the early preg-nancy TyG index,they were categorized into Tigroup(＜8.273,n=176),T2group(8.273-8.590,n=175),T3group(≥8.590,n=176).The glucose and lipid metabolism at different stages of pregnancy and maternal-fetal outcomes among the three groups were compared,and to explore the influence of the TyG index on on glucose and lipid metabolism.Results As the TyG index increased in the three groups,gestational times,delivery times,newborn weight,rates of macrosomia,and cesarean section all increased significantly(P＜0.05).In the third pregnancy and postpartum,total cholesterol,high-density lipoprotein cholesterol and triglycerides increased,while low-density lipoprotein cholesterol decreased,showing statistical significance(P＜0.05).Further analysis during the postpartum period revealed no statistical differences in impaired fasting glucose and impaired glucose tolerance among the groups(P＞0.05).Howev-er,the incidence of abnormal lipid metabolism such as hypercholesterolemia,hypertriglyceridemia,and decreased high-density lipopro-tein cholesterol significantly increased,and the difference was statistically significant(P＜0.05).Conclusion A high TyG index in ear-ly pregnancy can impact lipid metabolism in the third pregnancy and the postpartum period for women with gestational diabetes mellitus,increasing the occurrence of lipid metabolism abnormalities.
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