Association between Single Nucleotide Polymorphism of rs556621 and Recurrence of Ischemic Stroke in Patients with Symptomatic Intracrani-al Atherosclerosis Disease
Objective To explore the association between single nucleotide polymorphism(SNP)of rs556621 and recurrence of is-chemic stroke(IS)in patients with symptomatic intracranial atherosclerotic disease(sICAD).Methods This prospective,single-cen-ter cohort study consecutively enrolled patients with sICAD admitted to the Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine from March 2017 to October 2019.Genotyping analysis was performed through a TaqMan assay,clinical data related to stroke risk factors were collected,and stroke recurrence were recorded through the 2-year follow-up.The patients were divided into re-current group and non-recurrent group according to the recurrence situation,univariate analysis was used to compare the differences in stroke risk factors and distribution of rs556621 variants under dominant,recessive and allele models between participants.Multivariate COX regression analysis was applied to analyze the independent risk factors for recurrence of IS in sICAD.Results Fifty-eight sICAD patients were included in this study,and their cumulative recurrence rates of IS at 1 year and 2 years were 12.07％and 20.69％,respec-tively.Genotype analysis showed notable deviations from Hardy-Weinberg equilibrium at rs556621 locus,suggesting its potential role in ICAD susceptibility.Univariate analysis showed that the serum total cholesterol and high-density lipoprotein cholesterol in recurrent group were significantly lower than those in non-recurrent group,and the difference was statistically significant(P＜0.05).In the domi-nant genetic analysis mode,although there was no statistically significant difference in the genotype distribution of rs556621 between the two groups(P=0.096),it suggested that the dominant genetic effect of this locus may have potential effect on recurrence of IS.Multiva-riate COX regression analysis showed that patients with TT genotype at rs556621had a higher risk of 2-year recurrence of IS compared with carriers of CC or CT genotype(OR=4.659,95％CI:1.179-18.411,P=0.028).Conclusion Under dominant genetic analy-sis model,TT genotype at rs556621 is an independent risk factor for recurrence of IS in sICAD patients.
万方数据
维普
