Objective To investigate the white matter microstructural and cognitive damage of ending-stage renal disease(ESRD)patients with secondary hyperparathyroidism(SHPT).Methods 20 hospitalized patients diagnosed with ESRD combined with SHPT in the Department of Nephrology at the Second Affiliated Hospital of Anhui Medical University from May 2015 to June 2016 were selected as the SHPT group.20 healthy control individuals matched in age,gender,and education level were recruited as the healthy control group.3T MR sagittal structure images,diffusion tensor images,the Mini-Mental State Examination(MMSE)and the Montreal Cognitive Assessment(MOCA)scores for all subjects and parathyroid hormone(PTH)data of SHPT patients were collected.Image data was analyzed by using FMRIB Software Library(FSL)software.Results Anisotropy(FA)decreased significantly in ESRD patients with SHPT,mean diffusivity(MD)and radial diffusivity(RD)increased,and cognitive function decreased significantly.Conclusion The cognitive function of ESRD patients with SHPT is impaired,the white matter injury is widely and symmetrically distributed,and the degree of axon injury is similar to demyelination.
维普
万方数据