Objective To explore the MRI image characteristics of first-episode adult anti-myelin oligodendrocyte glycoprotein-IgG(MOG-IgG)associated disorders(MOGAD).Methods The general data,clinical phenotype,and MRI imaging data of 16 adult patients with first-episode MOGAD who were admitted to the Department of Neurology of Beijing Dawang Road Emergency Hospital and Beijing Chaoyang Integrative Medicine Emergency Hospital from June 2020 to June 2023 were retrospectively analyzed.Results Among the 16 patients,6 were males and 10 were females,with a median age of 37 years.Before treatment,all patients had lesions on MRI examination:7 cases(43.8%)involved the optic nerve,6 cases(37.5%)involved the cerebral cortex,2 cases(12.5%)involved the leptomeninges,2 cases(12.5%)involved the thoracic spinal cord,and 1 case(6.3%)involved the pons.There were 15 cases(93.7%)with enhancement and 1 case(6.3%)without enhancement.After 2 months of immunotherapy,the extent,number and intensification of MRI lesions in some patients were improved compared with before.Conclusion Although MRI image features cannot be used as a specific indicator for diagnosing MODAD,patients with optic neuritis,meningoencephalitis,brainstem encephalitis,and myelitis lesions with some enhancements should be highly vigilant for the possibility of MODAD,and immunotherapy has a certain effect on the disease.
维普
万方数据