Objective To explore the application of 3D amide proton transfer(3D-APT)imaging technology in nasopharyngeal carcinoma(NPC).Methods The clinical and imaging data of 22 patients with pathologically confirmed nasopharyngeal carcinoma admitted to Shenzhen Hospital,Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College from December 2019 to March 2020 were retrospectively analyzed,and the display effect of 3D-APT images on nasopharyngeal lesions was evaluated.The differences in APT values and tumor stage between nasopharyngeal carcinoma lesions and normal nasopharyngeal and cervical tissues were compared by t-test and univariate ANOVA test.Results On 3D-APT,10 cases could partially show nasopharyngeal carcinoma lesions,and 12 cases could completely show nasopharyngeal carcinoma lesions.The APT value of nasopharyngeal carcinoma lesions was higher than that of normal nasopharyngeal tissues(P＜0.01),and the APT values of nasopharyngeal carcinoma lesions with different N and M stages were statistically significant(P＜0.05),and the APT values of nasopharyngeal carcinoma lesions and neck muscles and parotid gland were statistically significant(P＜0.05).There was no significant difference in APT values between nasopharyngeal carcinoma lesions with different T stages and overall tumor stages(P＞0.05).There was no significant difference in APT values between nasopharyngeal carcinoma and bilateral cerebellum(P＞0.05).Conclusion 3D-APT imaging clearly shows nasopharyngeal carcinoma lesions,and the technology is feasible.NPC showed higher significant APT effect than normal nasopharyngeal tissue,or among muscles and parotid gland,facilitating NPC lesion detection and early identification.
Nasopharyngeal carcinomaAmide proton transfer imagingChemical exchange saturation transferMRI
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