肝细胞癌中GPC3的作用机制及影像组学的研究进展
Research progress on the mechanism and radiomics of GPC3 in hepatocellular carcinoma
郑紫涵 1许俊锋1
作者信息
- 1. 大理大学临床医学院 云南 大理 671000
- 折叠
摘要
肝细胞癌(HCC)是最常见的危害人类生命的恶性肿瘤之一,是世界上第二大癌症死亡原因.HCC发病机制隐匿,进展迅速,预后差,死亡率高,早期诊断和预测治疗后反应对HCC患者至关重要.磷脂酰肌醇蛋白聚糖-3(GPC3)是一种细胞表面糖蛋白,在HCC组织中过度表达,在健康成人肝脏中不表达,是诊断肝细胞癌的可靠免疫组化标志物.影像组学是最近发展起来的一项新兴技术,可以基于大量的高通量数据来量化肿瘤的特征,目前正逐步应用于肝癌的诊断、治疗和预后评估.本文就HCC GPC3 的作用机制及影像组学的研究进展进行综述.
Abstract
Hepatocellular carcinoma(HCC)is the second most prevalent cause of cancer-related death worldwide and one of the most common malignant tumors that pose a threat to human life.HCC is characterized by insidious pathogenesis,rapid progression,poor prognosis and high mortality.Early diagnosis and prediction of response after treatment are essential for HCC patients.Glypican-3(GPC3)is a cell surface glycoprotein that is overexpressed in HCC tissues but not in the liver of healthy adults.It is a reliable immunohistochemical marker for the diagnosis of hepatocellular carcinoma.Radiomics is an emerging technology developed recently,which can quantify the characteristics of tumors based on a large number of high-throughput data,and is now gradually applied to the diagnosis,treatment and prognosis evaluation of liver cancer.In this paper,the mechanism of HCC GPC3 and the research progress of radiomics are reviewed.
关键词
肝细胞癌/磷脂酰肌醇蛋白聚糖3/影像组学/综述Key words
Hepatocellular carcinoma/Glypican-3/Radiomics/Review引用本文复制引用
基金项目
云南省教育厅科研项目(2023Y0995)
出版年
2024
NETL
NSTL
万方数据