Objective To use MRI quantitative susceptibility mapping(QSM)to analyze the changes in magnetic sensitivity values of various basal nuclei in patients with Parkinson's disease(PD).Methods Fifteen PD patients diagnosed in People's Hospital of Ningxia Hui Autonomous Region were selected,and 20 healthy volunteers matched in gender and age during the same period were selected as the control group.All patients underwent QSM,and the magnetic sensitivity values of the bilateral head of the caudate nucleus,globus pallidus,putamen,red nucleus,substantia nigra,and bilateral cerebellar dentate nucleus were measured on QSM.The independent sample t-test was used to compare the differences in magnetic sensitivity values of gray matter nuclei between the PD group and the healthy control group.Results There was no significant difference in magnetic sensitivity between PD patients and the healthy control group in terms of bilateral caudate head,bilateral globus pallidus,bilateral putamen,and left dentate nucleus(P>0.05).The magnetic sensitivity values of the bilateral substantia nigra and nucleus rubra in PD patients were higher than those in the healthy control group,and the differences were statistically significant(P<0.05).The sensitivity value of right cerebellar dentate magnetic resonance imaging in Parkinson's patients was higher than that in the contralateral side,and the difference was statistically significant(P<0.05).Conclusion QSM can serve as a non-invasive method for quantitative measurement of iron content in brain tissue of PD patients.The magnetic sensitivity values of the red nucleus and substantia nigra in PD patients were significantly higher than those in the normal control group.QSM provides a reliable imaging basis for the early diagnosis of PD patients,which is of great significance for evaluating the patient's condition and selecting treatment plans.It has important clinical application value in clinical practice.
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