Objective To analyze the efficacy of ultrasound-guided microwave ablation in the treatment of papillary thyroid microcarcinoma(PTMC).Methods 50 patients with PTMC who received ultrasound-guided microwave ablation treatment at Dehong Prefecture People's Hospital from May 2022 to January 2023 for follow-up investigation were selected.Thyroid function was evaluated before and 1,3,and 12 months after surgery,and the absorption and metastasis of the ablation lesion were statistically analyzed.Results After treatment,it was found that there were 2 patients with local pain,but there was some relief on the 2nd day,and the number of other complications was 0.Before surgery,the concentrations of thyroid stimulating hormone,triiodothyronine,and free thyroid hormone were(2.95±1.83)μIU/mL,(3.22±0.57)pg/mL,and(0.84±0.21)ng/dL,respectively.One month after ablation,the levels of thyroid stimulating hormone,triiodothyronine,and free thyroid hormone were(2.98±1.62)μIU/mL,(3.20±0.61)pg/mL,and(0.93±0.12)ng/dL,respectively,with no statistically significant difference(P>0.05).The preoperative lesion volume was(78.22±49.57)mm3,while the postoperative lesion volumes at 1 month,3 months,and 12 months were(115.44±42.44)mm3,(31.42±24.43)mm3,and(0.53±2.98)mm3,respectively,with statistical significance(P<0.05).There was a statistically significant difference(t=4.033,P<0.05)between one month after surgery and before surgery.The reduction rates of lesion volume at 1 month,3 months,and 12 months after surgery were(-88.24±58.64)%,(69.72±22.45)%,and(99.88±2.55)%,respectively,with significant difference(P<0.05).Conclusion Microwave ablation has shown effectiveness,safety,and high treatment efficiency in the treatment of PTMC,and is worthy of further promotion and application.