Gas microbubbles,as a new type of photoacoustic contrast agent,have attracted widespread attention in the field of biomedical imaging due to their good biocompatibility,high imaging sensitivity,and ease of modification.However,the non targeting nature of gas microbubbles limits their clinical application.In order to improve the targeting and specificity of gas microbubbles as photoacoustic contrast agents,targeted modification is needed.This article reviews the targeted modification methods of gas microbubbles for photoacoustic contrast agents,including physical modification,chemical modification,and biological modification.The application of targeted modification of gas microbubbles as photoacoustic contrast agents in tumor imaging,inflammation imaging,infection imaging,and vascular imaging was elucidated.Analyze the advantages and limitations of targeted modification of gas microbubbles using photoacoustic contrast agents,and look forward to future development directions.
Gas microbubblesPhotoacoustic contrast agentTargeted modificationBiomedical imaging
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