冠状动脉CT-FFR值对冠心病患者不良心血管事件发生的影响
Predictive value of CT-FFR for major adverse cardiovascular events(MACE)in patients with coronary borderline lesions
刘琪 1窦勇 1王雅玲 1邓勇志2
作者信息
- 1. 山西省心血管病医院影像科CT室 山西 太原 030001
- 2. 山西省心血管病医院心血管外科 山西 太原 030001
- 折叠
摘要
目的:分析冠状动脉CT血流储备分数(CT-FFR)对冠心病患者不良心血管事件发生的影响.方法:选取 2016 年 6 月—2019年6月在山西省心血管病医院接受CCTA检查的84例冠心病患者作为研究对象,分析患者病变部位CT-FFR,比较CT-FFR阳性与阴性患者基础资料、主要不良心血管事件(心源性死亡、非致死性心肌梗死、不稳定性心绞痛以及接受靶血管血运重建治疗等)发生情况以及发生与未发生不良心血管事件患者CT-FFR及冠状动脉狭窄程度.结果:84 例患者共检测出病变 92 处,且CT-FFR阳性 31 例、阴性53 例.CT-FFR阳性患者年龄、性别、LV EF、高血压、高血脂、糖尿病病史、吸烟史及冠心病家族史与CT-FFR阴性患者无明显差异(P＞0.05),而血肌酐水平高于CT-FFR阴性患者,差异有统计学意义(P＜0.05).随访期间,CT-FFR阳性患者不良心血管事件发生率为38.7%,高于CT-FFR阴性患者不良心血管事件发生率3.8%,差异有统计学意义(P＜0.05).发生不良心血管事件患者CT-FFR阳性率及冠状动脉狭窄程度高于未发生不良心血管事件患者,差异有统计学意义(P＜0.05).结论:CT-FFR对冠心病患者不良心血管事件的发生起到重要预测作用,能够为冠心病患者诊疗策略的制定和提供指导.
Abstract
Objective To analyze the impact of coronary artery CT fractional flow reserve(CT-FFR)on adverse cardiovascular events in patients with coronary artery disease(CAD).Methods A total of 84 CAD patients who underwent coronary computed tomography angiography(CCTA)at Shanxi Cardiovascular Hospital between June 2016 and June 2019 were selected for the study.The CT-FFR of the lesion sites was analyzed,and the baseline data,major adverse cardiovascular events(MACE)(including cardiac death,non-fatal myocardial infarction,unstable angina,and target vessel revascularization),and the degree of coronary artery stenosis between CT-FFR positive and negative patients were compared.Results Among the 84 patients,a total of 92 lesions were detected,with 31 patients being CT-FFR positive and 53 patients being CT-FFR negative.There were no significant differences in age,gender,left ventricular ejection fraction(LVEF),history of hypertension,hyperlipidemia,diabetes,smoking,or family history of CAD between CT-FFR positive and negative patients(P>0.05).However,the creatinine levels were significantly higher in CT-FFR positive patients compared to CT-FFR negative patients(P<0.05).During the follow-up period,the incidence of adverse cardiovascular events was 38.7%in CT-FFR positive patients,significantly higher than the 3.8%incidence in CT-FFR negative patients(P<0.05).Patients who experienced adverse cardiovascular events had higher CT-FFR positive rates and more severe coronary artery stenosis compared to those who did not experience adverse events(P<0.05).Conclusion CT-FFR plays an important predictive role in the occurrence of adverse cardiovascular events in CAD patients and can provide guidance for the formulation of diagnosis and treatment strategies for these patients.
关键词
CT血流储备分数/冠心病/不良心血管事件/预测价值Key words
CT-FFR/Borderline lesions/MACE/Predictive value引用本文复制引用
出版年
2024
NETL
NSTL
万方数据