Objective To optimize the hepatobiliary phase delay time(HBP-DT)of Gd-EOB-DTPA enhanced MRI imaging for identifying hepatocellular carcinoma(HCC)lesions occurring in different liver function statuses.Methods A retrospective analysis of the Gd-EOB-DTPA-enhanced imaging and clinical data from 64 patients diagnosed with liver cancer at Guilin Medical University Affiliated Hospital from January 2015 to April 2022 were selected.Based on clinical data and Child-Pugh scores,patients were categorized into groups liver cirrhosis with Child-Pugh A(LCA),liver cirrhosis with Child-Pugh B(LCB)and liver cirrhosis with Child-Pugh C(LCC).The signal intensity(SI)of the non-contrast,arterial,portal,equilibrium phase,HBP-DT of 5,10,15 and 20 min after injection of Gd-EOB-DTPA were collected by selecting regions of interest on liver parenchyma and HCC.The ratio of liver SI to HCC SI was defined as LLR.The data were analyzed by two-way repeated measures of ANOVA.Results At HBP-DT 10 min,LLR had a significant difference among different Child-Pugh groups,which in LCA were higher significant than those in LCB and LCC,as well as at HBP-DT 15 and 20 min(P<0.05).Paired comparison showed that LLR had no statistic difference at arterial phase,HBP-DT 5,10 min in LCA(P>0.05),as well as at arterial phase,HBP-DT 5,10,15,20 min in LCB(P>0.05)and at arterial phase,HBP-DT 15,20 min in LCC(P>0.05).LLR had no statistic difference at HBP-DT 15,20 min in all Child-pugh groups(P>0.05).Conclusion Gd-EOB-DTPA has a great ability to identify HCC at arterial phase.With good liver function,the delayed scan could be shortened to 15 minutes,and with poor liver function,extending the hepatobiliary phase scan to 20 minutes does not enhance the lesion conspicuity beyond that achieved in the arterial phase.
Gd-EOB-DTPAMagnetic resonance imagingHepatobiliary phaseDelay time
维普
万方数据
