首页|衍生化法测定他达拉非中氯乙酰氯含量

衍生化法测定他达拉非中氯乙酰氯含量

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通过对氯乙酰氯衍生物含量的测定,间接测定氯乙酰氯在他达拉非中的含量.衍生物在浓度范围内,内线性关系良好.回收率和相对标准偏差在三个加样水平均符合要求.重复性、耐用性和稳定性试验表明:方法的重复性、耐用性和稳定性均符和要求.
Determination of Chloroacetyl Chloride in Tadalafil by Derivatization
The derivatives of chloroacetyl chloride in tadalafil was determined in order to detremine the contents of chloroacetyl chloride in tadalafil indirectly.The method had a good linearty,and recovery and relative standard deriviation of method was complied with requirment.It was indicated that repeatability,robustness and stability was complied with requirment.

chloroacetyl chloridetadalfilderivatizationdetermination

王亚虎、周微、唐海、王晓毅

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江苏天士力帝益药业有限公司,天津 300410

氯乙酰氯 他达拉非 衍生化 测定

2024

化工与医药工程
全国医药设计信息中心站

化工与医药工程

影响因子:0.19
ISSN:2095-817X
年,卷(期):2024.45(2)
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